西安交通大学学报（医学版）
西安交通大學學報（醫學版）
서안교통대학학보（의학판）
JOURNAL OF XI'AN JIAOTONG UNIVERSITY(MEDICAL SCIENCES)
2010年
1期
1-9
,共9页
mTOR信号通路%雷帕霉素%mTOR抑制剂%肿瘤治疗
mTOR信號通路%雷帕黴素%mTOR抑製劑%腫瘤治療
mTOR신호통로%뢰파매소%mTOR억제제%종류치료
mTOR signaling pathway%rapamycin%mTOR inhibitor%tumor therapy
哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin, mTOR)是一种丝/苏氨酸蛋白激酶,在细胞生长、增殖、分化、细胞周期调控等多个方面起到重要作用.近年来发现mTOR相关的信号通路复杂且涉及面广泛,其中多个元素的调控异常都与肿瘤的发生密切相关.mTOR抑制剂能够抑制由于该信号通路异常引起的癌基因的转化、肿瘤的生长和肿瘤血管生成.到目前为止,4种mTOR抑制剂被有效地应用于临床,有的已进入Ⅱ、Ⅲ期临床试验.因此,对mTOR信号通路的深入研究对肿瘤的靶向性治疗具有重要意义.
哺乳動物雷帕黴素靶蛋白(mammalian target of rapamycin, mTOR)是一種絲/囌氨痠蛋白激酶,在細胞生長、增殖、分化、細胞週期調控等多箇方麵起到重要作用.近年來髮現mTOR相關的信號通路複雜且涉及麵廣汎,其中多箇元素的調控異常都與腫瘤的髮生密切相關.mTOR抑製劑能夠抑製由于該信號通路異常引起的癌基因的轉化、腫瘤的生長和腫瘤血管生成.到目前為止,4種mTOR抑製劑被有效地應用于臨床,有的已進入Ⅱ、Ⅲ期臨床試驗.因此,對mTOR信號通路的深入研究對腫瘤的靶嚮性治療具有重要意義.
포유동물뢰파매소파단백(mammalian target of rapamycin, mTOR)시일충사/소안산단백격매,재세포생장、증식、분화、세포주기조공등다개방면기도중요작용.근년래발현mTOR상관적신호통로복잡차섭급면엄범,기중다개원소적조공이상도여종류적발생밀절상관.mTOR억제제능구억제유우해신호통로이상인기적암기인적전화、종류적생장화종류혈관생성.도목전위지,4충mTOR억제제피유효지응용우림상,유적이진입Ⅱ、Ⅲ기림상시험.인차,대mTOR신호통로적심입연구대종류적파향성치료구유중요의의.
Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase that is centrally involved in the control of cell growth, proliferation, differentiation and cell cycle regulation. Recent studies have found that the mTOR pathway is complicated and the dysregulation of mTOR pathway is recognized to be associated with lots of tumors. Several inhibitors of mTOR could inhibit oncogene transformation, growth and angiogenesis of tumors. So far, four inhibitors of mTOR have been tested in clinical trials, and some have been accessed to phase Ⅱ or Ⅲ trial. Therefore, in this review, we discuss the regulators that govern mTOR pathway activity, and highlight clinical results obtained with the first generation of mTOR inhibitors to reach the oncology clinics.
