中国地方病学杂志
中國地方病學雜誌
중국지방병학잡지
CHINESE JOURNAL OF ENDEMIOLOGY
2011年
2期
127-129
,共3页
赵树君%孙富军%叶艳%田恩江%陈祖培
趙樹君%孫富軍%葉豔%田恩江%陳祖培
조수군%손부군%협염%전은강%진조배
碘%血脂异常%甲状腺激素类%甲状腺功能减退症
碘%血脂異常%甲狀腺激素類%甲狀腺功能減退癥
전%혈지이상%갑상선격소류%갑상선공능감퇴증
Iodine%Dyslipidemia%Thyroid hormones%Hypothyroidism
目的 观察碘缺乏和碘过量对实验性甲状腺功能减退(简称甲减)小鼠血脂代谢的影响,探讨碘不依赖于甲状腺激素的独立作用机制.方法 将雌性Balb/c小鼠按体质量随机分为6组:对照、重度低碘(SID)、轻度低碘(MID)、适碘(NI)、10倍碘过量(10HI)和50倍碘过量(50HI)组,每组10只.对照组饲以低碘饲料,其他各组饲以含0.2%甲基硫氧嘧啶的低碘饲料,同时饮用碘化钾(KI)配制的含碘量分别为326.79、0、196.08、326.79、3856.21、19 542.50 μg/L的去离子水.喂养3个月后,处死并收集小鼠外周血,分离血清.放射免疫分析法测定甲状腺激素水平,酶法检测血清中甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)水平.结果 ①SID[(21.27±9.63)μg/L]、MID[(23.41±3.93)μg/L]、NI[(22.57±4.66)μg/L]、10HI[(21.07±5.03)μg/L]和50HI组[(21.46±5.90)μg/L]血清TT4水平明显低于对照组[(42.15±8.26)μg/L,P均＜0.01],而各组间血清TT3水平比较,差异无统计学意义(F=0.99,P＞0.05).②10HI组TG水平[(1.17±0.16)mmol/L]与对照组[(1.39±0.22)mmol/L]和NI组[(1.51±0.22)mmol/L]比较,明显降低(P均＜0.05).50HI组TG和TC水平[(1.18±0.22)、(1.78±0.15)mmol/L]与对照组[(1.39±0.22)、(2.14±0.37)mmol/L]和NI组[(1.51±0.22)、(2.00±0.15)mmol/L]比较,明显降低(P均＜0.05).各组HDL-C、LDL-C水平比较,差异无统计学意义(F值分别为0.55、0.54,P均＞0.05).结论 碘可不依赖于甲状腺激素独立发挥调节甲减小鼠血脂的作用;监控碘的摄入量,对有效防治心血管疾病亦有重要作用.
目的 觀察碘缺乏和碘過量對實驗性甲狀腺功能減退(簡稱甲減)小鼠血脂代謝的影響,探討碘不依賴于甲狀腺激素的獨立作用機製.方法 將雌性Balb/c小鼠按體質量隨機分為6組:對照、重度低碘(SID)、輕度低碘(MID)、適碘(NI)、10倍碘過量(10HI)和50倍碘過量(50HI)組,每組10隻.對照組飼以低碘飼料,其他各組飼以含0.2%甲基硫氧嘧啶的低碘飼料,同時飲用碘化鉀(KI)配製的含碘量分彆為326.79、0、196.08、326.79、3856.21、19 542.50 μg/L的去離子水.餵養3箇月後,處死併收集小鼠外週血,分離血清.放射免疫分析法測定甲狀腺激素水平,酶法檢測血清中甘油三酯(TG)、總膽固醇(TC)、高密度脂蛋白膽固醇(HDL-C)及低密度脂蛋白膽固醇(LDL-C)水平.結果 ①SID[(21.27±9.63)μg/L]、MID[(23.41±3.93)μg/L]、NI[(22.57±4.66)μg/L]、10HI[(21.07±5.03)μg/L]和50HI組[(21.46±5.90)μg/L]血清TT4水平明顯低于對照組[(42.15±8.26)μg/L,P均＜0.01],而各組間血清TT3水平比較,差異無統計學意義(F=0.99,P＞0.05).②10HI組TG水平[(1.17±0.16)mmol/L]與對照組[(1.39±0.22)mmol/L]和NI組[(1.51±0.22)mmol/L]比較,明顯降低(P均＜0.05).50HI組TG和TC水平[(1.18±0.22)、(1.78±0.15)mmol/L]與對照組[(1.39±0.22)、(2.14±0.37)mmol/L]和NI組[(1.51±0.22)、(2.00±0.15)mmol/L]比較,明顯降低(P均＜0.05).各組HDL-C、LDL-C水平比較,差異無統計學意義(F值分彆為0.55、0.54,P均＞0.05).結論 碘可不依賴于甲狀腺激素獨立髮揮調節甲減小鼠血脂的作用;鑑控碘的攝入量,對有效防治心血管疾病亦有重要作用.
목적 관찰전결핍화전과량대실험성갑상선공능감퇴(간칭갑감)소서혈지대사적영향,탐토전불의뢰우갑상선격소적독립작용궤제.방법 장자성Balb/c소서안체질량수궤분위6조:대조、중도저전(SID)、경도저전(MID)、괄전(NI)、10배전과량(10HI)화50배전과량(50HI)조,매조10지.대조조사이저전사료,기타각조사이함0.2%갑기류양밀정적저전사료,동시음용전화갑(KI)배제적함전량분별위326.79、0、196.08、326.79、3856.21、19 542.50 μg/L적거리자수.위양3개월후,처사병수집소서외주혈,분리혈청.방사면역분석법측정갑상선격소수평,매법검측혈청중감유삼지(TG)、총담고순(TC)、고밀도지단백담고순(HDL-C)급저밀도지단백담고순(LDL-C)수평.결과 ①SID[(21.27±9.63)μg/L]、MID[(23.41±3.93)μg/L]、NI[(22.57±4.66)μg/L]、10HI[(21.07±5.03)μg/L]화50HI조[(21.46±5.90)μg/L]혈청TT4수평명현저우대조조[(42.15±8.26)μg/L,P균＜0.01],이각조간혈청TT3수평비교,차이무통계학의의(F=0.99,P＞0.05).②10HI조TG수평[(1.17±0.16)mmol/L]여대조조[(1.39±0.22)mmol/L]화NI조[(1.51±0.22)mmol/L]비교,명현강저(P균＜0.05).50HI조TG화TC수평[(1.18±0.22)、(1.78±0.15)mmol/L]여대조조[(1.39±0.22)、(2.14±0.37)mmol/L]화NI조[(1.51±0.22)、(2.00±0.15)mmol/L]비교,명현강저(P균＜0.05).각조HDL-C、LDL-C수평비교,차이무통계학의의(F치분별위0.55、0.54,P균＞0.05).결론 전가불의뢰우갑상선격소독립발휘조절갑감소서혈지적작용;감공전적섭입량,대유효방치심혈관질병역유중요작용.
Objective To observe the effects of iodine deficiency and iodine excess on the lipid metabolism in an experimental hypothyroid model of mice and to explore the roles of iodine independent of its role in thyroid hormones. Methods Female Balb/c mice were randomly divided into 6 groups: control, severe iodine deficiency (SID), mild iodine deficiency(MID), normal iodine (NI), 10-fold high iodine (10HI) and 50-fold high iodine(50HI), 10 in each group. The mice in control group were fed with low iodine forage, other mice were fed with low iodine forage containing 0.2% methylthiouracilum. All mice drank deionic water containing different concentrations of potassium iodide(KI). The iodine content in water was 326.79, 0, 196.08,326.79, 385621, 19 542.50 μg/L, respectively. After three months, thyroid hormones in the serum were determined by radioimmunoassay.Also, the blood samples were analyzed for total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesteiol (HDL-C) and low density lipoprotein cholesterol (LDL-C) and measured enzymatically by automatic analyzer. Results ①The levels of Tr4 in SID[(21.27 ± 9.63)μg/L], MID[(23.41 ± 3.93)μg/L], NI[(22.57 ±4.66)μg/L], 10HI [(21.07 ± 5.03) μg/L] and 50HI groups [(21.46 ± 5.90) μg/L] were distinctively decreased compared with control group[(42.15 ± 8.26)μg/L, all P ＜ 0.01]. There were no statistical significant differences of
TT3 between different groups (F = 0.99, P > 0.05 ). ②The level of TG in 10HI group [ ( 1.17 ± 0.16)mmol/L ] was obviously decreased compared with control [(1.39 ± 0.22 )mmol/L] and NI groups[(151 ± 0.22)mmol/L, all P＜ 0.05].Both TG and TC in 50HI group[(1.18 ± 0.22), (1.78 ± 0.15)mmol/L] were significantly decreased compared with control [( 1.39 ± 0.22), (2.14 ± 0.37)mmol/L] and NI groups [(1.51 ± 0.22), (2.00 ± 0.15)mmol/L, all P ＜ 0.05].The difference of serum HDL-C and LDL-C between the groups was not significant(F = 0.55,0.54, all P ＞ 0.05 ).Conclusions Dietary iodine plays a role in the metabolism of serum lipids independent of thyroid hormones.Thus, monitoring the amount of iodine intake during sodium restriction should also be taken extremely important for effectively prevention and cure of cardiovascular disease.
