CAJ | 학술논문

目的探讨肠球菌属的分布特征及耐药性变迁,为临床治疗提供参考.方法回顾性分析2001至2007年湖州市中心医院和湖州市第一人民医院各类临床标本中分离出的肠球菌属的分布特点、检出率及药物敏感性.结果 94876份临床标本中检出肠球菌2547株(2.68%),其中粪肠球菌为主要菌种,屎肠球菌次之.肠球菌属在各种临床标本中的分布仍以尿液为主,痰液标本中肠球菌属的比例逐年增加.肠球菌属对红霉素、利福平、环丙沙星和左氧氟沙星具有较高的耐药性.粪肠球菌对青霉素、氨苄西林和呋喃妥因敏感性较好;屎肠球菌的耐药率逐年上升,但对四环素和氯霉素的耐药率低于粪肠球菌.肠球菌属对万古霉素和替考拉宁仍然保持很高的敏感性.结论肠球菌属感染以粪肠球菌和屎肠球菌为主,由其引起的呼吸道感染在增加.肠球菌届的总体耐药率较高,临床上应根据药物敏感性试验结果选择敏感的抗菌药物治疗.
목적 탐토장구균속적분포특정급내약성변천,위림상치료제공삼고.방법 회고성분석2001지2007년호주시중심의원화호주시제일인민의원각류림상표본중분리출적장구균속적분포특점、검출솔급약물민감성.결과 94876빈림상표본중검출장구균2547주(2.68%),기중분장구균위주요균충,시장구균차지.장구균속재각충림상표본중적분포잉이뇨액위주,담액표본중장구균속적비례축년증가.장구균속대홍매소、리복평、배병사성화좌양불사성구유교고적내약성.분장구균대청매소、안변서림화부남타인민감성교호;시장구균적내약솔축년상승,단대사배소화록매소적내약솔저우분장구균.장구균속대만고매소화체고랍저잉연보지흔고적민감성.결론 장구균속감염이분장구균화시장구균위주,유기인기적호흡도감염재증가.장구균계적총체내약솔교고,림상상응근거약물민감성시험결과선택민감적항균약물치료.
Objective To investigate the characteristics of distribution and the changes in drug resistance of Enterococci,providing reference for clinical treatment.Methods The distribution and drug resistance in 2547 clinical isolates of Enterococci from 2001 to 2007 in Huzhou Central Hospital and the First People's Hospital of Huzhou were retrospectively analyzed.Results A total of 2547 strains of Enterococci were isolated from 94876 clinical specimens(2.68%),in which Enterococcus faecalis wag primary and Enterococcus faecium Wag ranking the second.The positive rate of Enterococci in urine specimens was the highest,and that in sputum specimens was increasing recently.Enterococci showed higg resistance to erythromycin,rifampin,ciprofloxacin and levofloxacin;Enterococcus faecalis Wag more sensitive to penicillin,ampiciilin and ndtrofurantoin than Enterococcus faecium,while Euterococcus faecium was more sensitive to chloramphended and tetracycline than Enterococcus faecalis;both of them were sensitive to vaneomycin and teicoplanin.Conclusions Enterococcus faecalis and Enterococcus faecium are the common pathogen in Enterococci infections.Enterococci show high drug resistance,so the clinical use of antibiotics should be based on the resuhs of drug sensitivity test.