CAJ | 학술논문

自噬是细胞清除受损或多余的蛋白质和细胞器的降解过程.最近研究发现,脂滴也是自噬过程的底物之一.在营养状态改变时,自噬能够根据机体需要增加或减少对脂滴的降解,从而起到调节脂代谢的作用.此外,自噬在脂滴形成及脂肪组织分化过程中也发挥重要作用.在细胞水平以自噬为靶点是治疗肥胖、胰岛素抵抗和2型糖尿病的新途径.
자서시세포청제수손혹다여적단백질화세포기적강해과정.최근연구발현,지적야시자서과정적저물지일.재영양상태개변시,자서능구근거궤체수요증가혹감소대지적적강해,종이기도조절지대사적작용.차외,자서재지적형성급지방조직분화과정중야발휘중요작용.재세포수평이자서위파점시치료비반、이도소저항화2형당뇨병적신도경.
Autophagy is a celler degradation pathway in which damaged or superfluous proteins and organelles are cleared.Recently,lipid droplets (LDs) have been identified as a substrate for macroautophagy.The ability of autophagy to respond to changes in nutrient supply allows the cell to alter LD metabolism to meet the cell's energy demands.In addition,autophagy plays an important roles in the formation of LD and differentiation of lipid tissue.Autophagy therefore represents a new cellular target for abnormalities in lipid metabolism and accumulation.