CAJ | 학술논문

目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清甲状腺素水平以及在OSAHS病情进展中的作用.方法选择OSAHS患者和健康者(对照组)各40例,均为男性,分别行多导睡眠图检查,并测定空腹甲状腺素水平.结果 ①OSAHS肥胖组的颈围为(43.56±3.48)cm,对照肥胖组为(38.33±3.08)cm,2组比较差异有统计学意义(t=4.258,P<0.05);OSAHS非肥胖组的颈围为(40.50±1.05)cm,对照非肥胖组为(36.17±3.13)cm,2组比较差异有统计学意义(t=3.146,P<0.05).OSAHS肥胖组的FT3水平为(6.35±3.15)pmol/L,对照肥胖组为(4.08±2.37)pmol/L,2组比较差异有统计学意义(t=2.203,P<0.05):OSAHS非肥胖组的FT3水平为(3.42±0.57)pmol/L,对照非肥胖组为(2.46±0.31)pmol/L,2组比较差异有统计学意义(t=2.187,P<0.05).②OSAHS患者FT3与低通气指数及微觉醒指数均呈正相关(r=0.500,P<0.05;r=0.561,P<0.05),FT4仅与微觉醒指数呈正相关(r=0.542,P<0.05).③OSAHS患者FT3与颈围呈正相关(r=0.489,P<0.05),促甲状腺素与颈围呈负相关(r=-0.500,P<0.05),促甲状腺素与脂肪百分比呈正相关(r=0.498,P<0.05).结论 OSAHS患者FT3浓度虽均在正常范围内,但明显高于对照组,提示OSAHS患者有出现代谢异常的趋势.同时FT3与颈围存在明显的相关性,提示OSAHS患者颈围的增加与甲状腺素相关.
목적 탐토조새성수면호흡잠정저통기종합정(OSAHS)환자혈청갑상선소수평이급재OSAHS병정진전중적작용.방법 선택OSAHS환자화건강자(대조조)각40례,균위남성,분별행다도수면도검사,병측정공복갑상선소수평.결과 ①OSAHS비반조적경위위(43.56±3.48)cm,대조비반조위(38.33±3.08)cm,2조비교차이유통계학의의(t=4.258,P<0.05);OSAHS비비반조적경위위(40.50±1.05)cm,대조비비반조위(36.17±3.13)cm,2조비교차이유통계학의의(t=3.146,P<0.05).OSAHS비반조적FT3수평위(6.35±3.15)pmol/L,대조비반조위(4.08±2.37)pmol/L,2조비교차이유통계학의의(t=2.203,P<0.05):OSAHS비비반조적FT3수평위(3.42±0.57)pmol/L,대조비비반조위(2.46±0.31)pmol/L,2조비교차이유통계학의의(t=2.187,P<0.05).②OSAHS환자FT3여저통기지수급미각성지수균정정상관(r=0.500,P<0.05;r=0.561,P<0.05),FT4부여미각성지수정정상관(r=0.542,P<0.05).③OSAHS환자FT3여경위정정상관(r=0.489,P<0.05),촉갑상선소여경위정부상관(r=-0.500,P<0.05),촉갑상선소여지방백분비정정상관(r=0.498,P<0.05).결론 OSAHS환자FT3농도수균재정상범위내,단명현고우대조조,제시OSAHS환자유출현대사이상적추세.동시FT3여경위존재명현적상관성,제시OSAHS환자경위적증가여갑상선소상관.
Objective To investigate the changes of serum thyroxine level in obstructive sleep apnea-hy-popnea syndrome(OSAHS) patients and to assess the role of serum thyroxine in the development of OSAHS. Meth-ods Polysomnography was used to examine the patients with OSAHS and fasting plasma serum thyroxine level were higher in obese OSAHS patients than in obese controls[ (43.56±3.48)cm vs (38.33±3.08)cm,t =4. 258,P < 0.05 ], in non-obese OSAHS patients than in non-obese control group [ (40.50±1.05 )cm vs (36.17±3.13 )cm, t = 3. 146 ,P < 0.05 ] . The levels of FT3 was (6.35±3.15 ) pmol/L in obese OSAHS patients and ( 4.08±2.37 ) pmol/L in control subjects ( t = 2.203 ,P < 0.05 ). That was ( 3.42±0.57 ) pmol/L in non-obese OSAHS patients related with AHI and microarousal index (r = 0. 500, P < 0.05;r = 0.561, P < 0.05 ), and FT4 was also positively with neck circumference( t = 0.489, P < 0.05 ), TSH level was negatively correlated with neck circumference ( t = - 0.500, P < 0.05 ) and was positively correlated with the percentage of body fat ( r = 0.498, P < 0.05 ). Conclu-sions The FT3 levels are significantly higher in the OSAHS patients than that in control subjects, though all FT3 lev-els are normal, suggesting that there are possibility to have abnormal metabolism. At the same time, FT3 level is posi-tively correlated with neck circumference ,suggesting that the OSAHS patients' higher neck circumference is correla-ted with thyroxine.