中国医药
中國醫藥
중국의약
CHINA MEDICINE
2012年
10期
1263-1264
,共2页
酒精性肝炎%异甘草酸镁%还原型谷胱甘肽
酒精性肝炎%異甘草痠鎂%還原型穀胱甘肽
주정성간염%이감초산미%환원형곡광감태
Alcoholic hepatitis%Magnesium isoglycyrrhizinate%Reduced glutathione
目的 观察异甘草酸镁对于酒精性肝炎的疗效.方法 选择益阳市中心医院2006年3月至2012年3月期间收治的酒精性肝炎患者80例,完全随机分为研究组(40例)和对照组(40例),研究组给予异甘草酸镁注射液150 mg溶于10％葡萄糖溶液250 ml,1次/d静脉滴注,同时应用多烯磷脂酰胆碱10 ml溶于10％葡萄糖溶液250 ml,1次/d静脉滴注.对照组予以还原型谷胱甘肽1.8g溶于10％葡萄糖溶液250 ml,1次/d静脉滴注,同时应用多烯磷脂酰胆碱10 ml溶于10％葡萄糖溶液250ml,1次/d静脉滴注,治疗时间2～3周.结果 研究组乏力、纳差、腹胀、黄疸、肝脏肿大和压痛减轻率均高于对照组(均P＜0.05).研究组治疗后ALT、AST、γ-谷氨酰转肽酶、总胆红素的水平均低于对照组(P＜0.05).研究组治疗总有效率明显高于对照组[87.5％(35/40)比70.0％(28/40)],差异有统计学意义(P＜0.05).结论 异甘草酸镁对于控制酒精性肝炎炎症活动有显著作用,且优于还原型谷胱甘肽.
目的 觀察異甘草痠鎂對于酒精性肝炎的療效.方法 選擇益暘市中心醫院2006年3月至2012年3月期間收治的酒精性肝炎患者80例,完全隨機分為研究組(40例)和對照組(40例),研究組給予異甘草痠鎂註射液150 mg溶于10％葡萄糖溶液250 ml,1次/d靜脈滴註,同時應用多烯燐脂酰膽堿10 ml溶于10％葡萄糖溶液250 ml,1次/d靜脈滴註.對照組予以還原型穀胱甘肽1.8g溶于10％葡萄糖溶液250 ml,1次/d靜脈滴註,同時應用多烯燐脂酰膽堿10 ml溶于10％葡萄糖溶液250ml,1次/d靜脈滴註,治療時間2～3週.結果 研究組乏力、納差、腹脹、黃疸、肝髒腫大和壓痛減輕率均高于對照組(均P＜0.05).研究組治療後ALT、AST、γ-穀氨酰轉肽酶、總膽紅素的水平均低于對照組(P＜0.05).研究組治療總有效率明顯高于對照組[87.5％(35/40)比70.0％(28/40)],差異有統計學意義(P＜0.05).結論 異甘草痠鎂對于控製酒精性肝炎炎癥活動有顯著作用,且優于還原型穀胱甘肽.
목적 관찰이감초산미대우주정성간염적료효.방법 선택익양시중심의원2006년3월지2012년3월기간수치적주정성간염환자80례,완전수궤분위연구조(40례)화대조조(40례),연구조급여이감초산미주사액150 mg용우10％포도당용액250 ml,1차/d정맥적주,동시응용다희린지선담감10 ml용우10％포도당용액250 ml,1차/d정맥적주.대조조여이환원형곡광감태1.8g용우10％포도당용액250 ml,1차/d정맥적주,동시응용다희린지선담감10 ml용우10％포도당용액250ml,1차/d정맥적주,치료시간2～3주.결과 연구조핍력、납차、복창、황달、간장종대화압통감경솔균고우대조조(균P＜0.05).연구조치료후ALT、AST、γ-곡안선전태매、총담홍소적수평균저우대조조(P＜0.05).연구조치료총유효솔명현고우대조조[87.5％(35/40)비70.0％(28/40)],차이유통계학의의(P＜0.05).결론 이감초산미대우공제주정성간염염증활동유현저작용,차우우환원형곡광감태.
Objective To investigate the effect of magnesium isoglycyrrhizinate in treatment of alcoholic hepatitis.Methods Eighty patients were randomly divided into treatment group(n =40)and control group(n =40). Patients in the treatment group were given magnesium isoglycyrrhizinate 150 mg and polyene phosphatidylcholine 10 ml once everyday.Patients in the control group were given reduced glutathione 1.8 g and polyene phosphatidylcholine 10 ml once everyday.The Course was 2-3 weeks.Changes of clinical manifestations,biochemical and immunological indexes were observed.Results Patients in both groups showed therapeutic effect with statistical significance(P ＜ 0.05).After treatment,the degree of biochemical indicators declined significantly in the treatment group than that of the control group(P ＜ 0.05).The total effective rate of the treatment group was significantly higher than that of control group [87.5％(35/40)vs 70.0％(28/40)].Conclusion The result shows that magnesium isoglycyrrhizinate and reduced glutathione are effective drugs for controlling inflammation activity of the alcoholic hepatitis and magnesium isoglycyrrhizinate is a more effective and safer agent than reduced glutathione.
