CAJ | 학술논문

目的调查社区高血压人群抗高血压药物的应用情况,分析不合理因素,指导社区临床用药.方法采用分层整群抽样方法,于2009年4月至6月对上海大华社区中3个居委和1个村的703例高血压患者进行问卷调查,对用药品种、类型、联合用药及合理性进行分析.结果在703例资料完整的高血压患者中,582例在服用高血压药物(82.8%),其中271例单用非复方制剂者治疗(38.5%),182例单用复方制剂(25.9%),2种药物联用的117例(16.8%),3种药物联用的12例(1.6%).包含单用复方制剂者在内合计有311例(53.4%)在服用2种及以上药物.服用钙离子拮抗剂(CCB)的患者266例,占服药人数的47.5%,服用复方制剂的205例,占35.2%.结论联合用药比例明显高于单一用药,三联治疗中遵循高血压防治指南较少;CCB在社区高血压人群用药中占主导地位;非长效复方制剂使用比例较高;建议加强社区医生高血压用药规范性的培训和高血压患者的社区管理.
목적 조사사구고혈압인군항고혈압약물적응용정황,분석불합리인소,지도사구림상용약.방법 채용분층정군추양방법,우2009년4월지6월대상해대화사구중3개거위화1개촌적703례고혈압환자진행문권조사,대용약품충、류형、연합용약급합이성진행분석.결과 재703례자료완정적고혈압환자중,582례재복용고혈압약물(82.8%),기중271례단용비복방제제자치료(38.5%),182례단용복방제제(25.9%),2충약물련용적117례(16.8%),3충약물련용적12례(1.6%).포함단용복방제제자재내합계유311례(53.4%)재복용2충급이상약물.복용개리자길항제(CCB)적환자266례,점복약인수적47.5%,복용복방제제적205례,점35.2%.결론 연합용약비례명현고우단일용약,삼련치료중준순고혈압방치지남교소;CCB재사구고혈압인군용약중점주도지위;비장효복방제제사용비례교고;건의가강사구의생고혈압용약규범성적배훈화고혈압환자적사구관리.
Objective To investigate use of oral antihypertensive drugs among community hypertensive patients in Shanghai and find out factors related to their unreasonable use to direct their clinical use. Methods Seven hundred and three hypertensive patients were surveyed with questionnaire by stratified cluster sampling at three neighborhoods and one village of Dahua community, Baoshan district, Shanghai during April to June 2009 to understand their use of antihypertensive agents, including kinds and forms of drugs, rationale of drug use. Results Five hundred and eighty-two (82. 8% ) of 703 hypertensive patients interviewed were using antihypertensive drugs, 271 (38. 5% ) of them used only one kind of non-compound antihypertensive drug, 182 (25.9%) used one kind of compound agent, 311 (53.4%) used two or more kinds of drugs in combination, including 117 patients ( 16. 8% ) used two kinds of agents combined and 12 patients ( 1.6% ) used three kinds of agents combined. Two hundred and sixty-six (47.5%) patients took orally calcium-channel blockers and 205 ( 35.2% ) used compound agents. Conclusions Frequency of combined use of two or more kinds of antihypertensive agents is reasonable and significantly higher than that of use of one kind of drug at Dahua community in Shanghai. Calcium channel blocker plays a predominant role in treatment for hypertension, non-long-acting compound agents are used in a higher proportion. But,guidelines for hypertension prevention and treatment are not so well complied with in local hypertensive patients. So, it is suggested that training for community physicians and management for standard use of antihypertensive agents at community should be strengthened further.