CAJ | 학술논문

分析研究了用固体光气为氯化剂提高盐酸克林霉素的收率和质量的问题;介绍了以盐酸林可霉素为原料,用固体光气作为氯化试剂,通过化学反应合成为盐酸克林霉素的工艺,提高了产品的纯度、收率和质量,降低了成本,特别是将盐酸克林霉素的质量收率提高到92%～93%（盐酸克林霉素千克数/林可霉素千克数）,技术指标符合中国药典（2010版）的要求。
분석연구료용고체광기위록화제제고염산극림매소적수솔화질량적문제;개소료이염산림가매소위원료,용고체광기작위록화시제,통과화학반응합성위염산극림매소적공예,제고료산품적순도、수솔화질량,강저료성본,특별시장염산극림매소적질량수솔제고도92%～93%（염산극림매소천극수/림가매소천극수）,기술지표부합중국약전（2010판）적요구。
Solid phosgene as chlorinating agent was used to improve the yield and quality of clindamycin hydrochloride problem.Lincomycin hydrochloride as raw material,solid phosgene as chloride reagent,chemical reaction clindamycin hydrochloride was synthesized,with high product purity,yield and quality,the cost was reduced,especially,clindamycin hydrochloride quality yield increased to 92%~93%（kg/forest of clindamycin hydrochloride lincomycin kilograms）,and technical indicators were in line with the Chinese Pharmacopoeia（2010 Edition） requirements.