国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2011年
10期
893-896
,共4页
王黎明%谭庆远%张岩%邱冠军%曲洪雪%张伟东
王黎明%譚慶遠%張巖%邱冠軍%麯洪雪%張偉東
왕려명%담경원%장암%구관군%곡홍설%장위동
软组织损伤%活血通络止痛膏
軟組織損傷%活血通絡止痛膏
연조직손상%활혈통락지통고
Soft issue injury%Huoxue-Tongluo-Zhitong ointment
目的 观察活血通络止痛膏治疗软组织损伤的疗效及皮肤给药的安全性.方法 以扶他林乳膏为对照组,以外表损伤指数为指标,结合病理切片观察活血通络止痛膏对家兔软组织损伤的疗效.采用新西兰大白兔进行动物实验,观察活血通络止痛膏的皮肤急毒性、刺激性、过敏性反应.结果 活血通络止痛膏可减少新西兰大白兔软组织损伤局部水肿及炎细胞渗出,促进血肿和瘀斑的吸收,外表损伤指数观察比较,A组[肿胀(0.32±0.35)分、淤斑(0.29±0.27)分]明显优于B组[肿胀(0.58±0.42)分、淤斑(0.91±0.34)分](P<0.05).A、B组的病理过程明显缩短,与C组比较差异均有统计学意义(P均<0.05).嗜中性粒细胞浸润密度测定,A、B组与C组比较差异均有统计学意义(P均<0.05),但A、B两组比较差异无统计学意义(P>0.05).结论 活血通络止痛膏对急性软组织损伤有效,安全性较高.
目的 觀察活血通絡止痛膏治療軟組織損傷的療效及皮膚給藥的安全性.方法 以扶他林乳膏為對照組,以外錶損傷指數為指標,結閤病理切片觀察活血通絡止痛膏對傢兔軟組織損傷的療效.採用新西蘭大白兔進行動物實驗,觀察活血通絡止痛膏的皮膚急毒性、刺激性、過敏性反應.結果 活血通絡止痛膏可減少新西蘭大白兔軟組織損傷跼部水腫及炎細胞滲齣,促進血腫和瘀斑的吸收,外錶損傷指數觀察比較,A組[腫脹(0.32±0.35)分、淤斑(0.29±0.27)分]明顯優于B組[腫脹(0.58±0.42)分、淤斑(0.91±0.34)分](P<0.05).A、B組的病理過程明顯縮短,與C組比較差異均有統計學意義(P均<0.05).嗜中性粒細胞浸潤密度測定,A、B組與C組比較差異均有統計學意義(P均<0.05),但A、B兩組比較差異無統計學意義(P>0.05).結論 活血通絡止痛膏對急性軟組織損傷有效,安全性較高.
목적 관찰활혈통락지통고치료연조직손상적료효급피부급약적안전성.방법 이부타림유고위대조조,이외표손상지수위지표,결합병리절편관찰활혈통락지통고대가토연조직손상적료효.채용신서란대백토진행동물실험,관찰활혈통락지통고적피부급독성、자격성、과민성반응.결과 활혈통락지통고가감소신서란대백토연조직손상국부수종급염세포삼출,촉진혈종화어반적흡수,외표손상지수관찰비교,A조[종창(0.32±0.35)분、어반(0.29±0.27)분]명현우우B조[종창(0.58±0.42)분、어반(0.91±0.34)분](P<0.05).A、B조적병리과정명현축단,여C조비교차이균유통계학의의(P균<0.05).기중성립세포침윤밀도측정,A、B조여C조비교차이균유통계학의의(P균<0.05),단A、B량조비교차이무통계학의의(P>0.05).결론 활혈통락지통고대급성연조직손상유효,안전성교고.
Objective To observe the curative effect of Huoxue-Tongluo-Zhitong ointment treating soft tissue injury,and the safety of application on skin.Methods The treatment group was treated with Huoxue-Tongluo-Zhitong ointment,while the comparison group was treated with Votalin Pill.Acute toxicity experiment,irritant experiment and hypersensitivity experiment of skin were performed on New Zealand white rabbits.Results Huoxue-Tongluo-Zhitong ointment decreased local edema and leukocyte effusion,accelerate the re-absorption of hematomas.On injury signs index,group A [ (0.32± 0.35),(0.29± 0.27) ] was better than group B [ (0.58±0.42),(0.91 ±0.34) ] (P<0.05).The pathological process in group A and B was obviously reduced than group C (P<0.05).In the neutruphil infiltration density measuring:compared with group C,group A and B both showed significant difference (P<0.05),but there was no significant difference between group A and B (P>0.05).Conclusion Huoxue-Tongluo-Zhitong ointment performed well on the treatment of soft issue injury,with no toxicity,irritation,and hypersensitivity of skin,as well as high safety of administration.