国际泌尿系统杂志
國際泌尿繫統雜誌
국제비뇨계통잡지
INTERNATIONAL JOURNAL OF UROLOGY AND NEPHROLOGY
2010年
1期
4-10
,共7页
胡溯%桂西青%王亚佟%郭振宇%詹鸣
鬍溯%桂西青%王亞佟%郭振宇%詹鳴
호소%계서청%왕아동%곽진우%첨명
输尿管结石%钙通道阻滞药
輸尿管結石%鈣通道阻滯藥
수뇨관결석%개통도조체약
Ureteral calculi%Calcium Charmel Blockers
目的 系统评价钙通道阻滞剂治疗输尿管结石的疗效.方法 电子检索Coehrane图书馆、Cochrane肾脏专业组记录、Cochrane系统评价资料库、Cochrane临床对照试验库(CENTRAL)、Pubmed、EMBASE、OVID、BIOSIS、中国生物医学文献数据库(CBM)、中国知网全文数据库(CNKI)、中文科技期刊全文数据库(VIP)等电子资料库,辅以手工检索及追查已纳入文献的参考文献.系统收集钙通道阻滞剂治疗输尿管结石的随机对照试验(RCT).由2名评价者共同评价纳入研究质量并提取资料,合并同质研究进行Mete分析,采用RevMan 4.2.10完成定量资料分析.结果 共纳入10个随机对照试验,包括882例输尿管结石患者.Meta分析结果显示:钙通道阻滞剂组比保守疗法结石排出率高[RR=1.50;95%CI(1.36～1.65);P＜0.00001],并降低后期住院治疗率[RR=0.42;95%CI(0.34～0.52);P＜0.00001],减少了平均排石时间及止痛药用量,并且钙通道阻滞剂组和保守疗法在药物副作用方面没有差异(P＞0.05).结论 钙通道阻滞剂对输尿管结石具有较高的促排石率,能缩短排石时间、降低后期人院治疗率及止痛药用量.
目的 繫統評價鈣通道阻滯劑治療輸尿管結石的療效.方法 電子檢索Coehrane圖書館、Cochrane腎髒專業組記錄、Cochrane繫統評價資料庫、Cochrane臨床對照試驗庫(CENTRAL)、Pubmed、EMBASE、OVID、BIOSIS、中國生物醫學文獻數據庫(CBM)、中國知網全文數據庫(CNKI)、中文科技期刊全文數據庫(VIP)等電子資料庫,輔以手工檢索及追查已納入文獻的參攷文獻.繫統收集鈣通道阻滯劑治療輸尿管結石的隨機對照試驗(RCT).由2名評價者共同評價納入研究質量併提取資料,閤併同質研究進行Mete分析,採用RevMan 4.2.10完成定量資料分析.結果 共納入10箇隨機對照試驗,包括882例輸尿管結石患者.Meta分析結果顯示:鈣通道阻滯劑組比保守療法結石排齣率高[RR=1.50;95%CI(1.36～1.65);P＜0.00001],併降低後期住院治療率[RR=0.42;95%CI(0.34～0.52);P＜0.00001],減少瞭平均排石時間及止痛藥用量,併且鈣通道阻滯劑組和保守療法在藥物副作用方麵沒有差異(P＞0.05).結論 鈣通道阻滯劑對輸尿管結石具有較高的促排石率,能縮短排石時間、降低後期人院治療率及止痛藥用量.
목적 계통평개개통도조체제치료수뇨관결석적료효.방법 전자검색Coehrane도서관、Cochrane신장전업조기록、Cochrane계통평개자료고、Cochrane림상대조시험고(CENTRAL)、Pubmed、EMBASE、OVID、BIOSIS、중국생물의학문헌수거고(CBM)、중국지망전문수거고(CNKI)、중문과기기간전문수거고(VIP)등전자자료고,보이수공검색급추사이납입문헌적삼고문헌.계통수집개통도조체제치료수뇨관결석적수궤대조시험(RCT).유2명평개자공동평개납입연구질량병제취자료,합병동질연구진행Mete분석,채용RevMan 4.2.10완성정량자료분석.결과 공납입10개수궤대조시험,포괄882례수뇨관결석환자.Meta분석결과현시:개통도조체제조비보수요법결석배출솔고[RR=1.50;95%CI(1.36～1.65);P＜0.00001],병강저후기주원치료솔[RR=0.42;95%CI(0.34～0.52);P＜0.00001],감소료평균배석시간급지통약용량,병차개통도조체제조화보수요법재약물부작용방면몰유차이(P＞0.05).결론 개통도조체제대수뇨관결석구유교고적촉배석솔,능축단배석시간、강저후기인원치료솔급지통약용량.
Objectives Here is a systematic evaluation of the use of calcium channel blocker to facilitate ureteral stone expulsion.Methods We searched the databases of the Cochrane library,Cochrane Reviews,Cochrane Renal Group,Cochrane Controlled Trials Register,Pubmed,EMBASE,OVID,BIOSIS,CBM,CNKI and VIP.Additional sources were obtained by a hand search.We did our best to get the full-text of the studies.which is included in the systematic review.We searched studies that incorporated a randomized controlled clinical trial design,treatment in which calcium channel blocker was compared to a standard therapy group,With the RevMan4.2.10,data from selected trials was abstracted and pooled by 2 of the authors.Resulm The study contained ten trials (number of patients=882).calcium-channel blocker compared to standard therapy significantly improved spontaneous stone expulsion[RR=1.50;95%CI(1.36～1.65);P＜0.130001],with decreasingthe rates of hospitalization.the mean Time to Expulsion and the mean amount of analgesic.No statistically significant difference was found in side effects between the treatment arm and control arm(P＞0.05).Conclusions Our results suggest that "medical expuisive thempy,"using calcium channel blockers,augments the stone expulsion rate compared to standard therapy for ureteral stone and diminishs the rates of hospitalization.the mean time to Expulsion and the mean amount of analgesic.
