CAJ | 학술논문

目的探讨肺癌VEGF-C表达与淋巴管生成及淋巴结转移CT影像的关系.方法搜集42例胸腔镜手术切除并经病理证实的非小细胞肺癌标本(肺癌组)和20例肺良性病变组织标本(对照组),术前常规CT扫描,术后对标本行VEGF-C、VEGFR-3免疫组化染色,比较两组VEGF-C表达及淋巴管密度(LVD)的差异,分析VEGF-C表达与淋巴结转移CT影像的关系.结果 NSCLC组VEGF-C阻性率(69.0％vs 5.0％,P＜0.01)、LVD水平(11.67±2.93 vs 3.81±1.39,P＜ 0.01)显著高于对照组.淋巴结转移CT影像表现为癌性淋巴管炎,肺门及纵隔淋巴结转移.淋巴结转移组VEGF-C阳性率显著高于无转移组(90％vs 31.8％,P＜ 0.01).结论肺癌组织存在VEGF-C的高表达,后者可能通过淋巴管生成促进淋巴结转移.
목적 탐토폐암VEGF-C표체여림파관생성급림파결전이CT영상적관계.방법 수집42례흉강경수술절제병경병리증실적비소세포폐암표본(폐암조)화20례폐량성병변조직표본(대조조),술전상규CT소묘,술후대표본행VEGF-C、VEGFR-3면역조화염색,비교량조VEGF-C표체급림파관밀도(LVD)적차이,분석VEGF-C표체여림파결전이CT영상적관계.결과 NSCLC조VEGF-C조성솔(69.0％vs 5.0％,P＜0.01)、LVD수평(11.67±2.93 vs 3.81±1.39,P＜ 0.01)현저고우대조조.림파결전이CT영상표현위암성림파관염,폐문급종격림파결전이.림파결전이조VEGF-C양성솔현저고우무전이조(90％vs 31.8％,P＜ 0.01).결론 폐암조직존재VEGF-C적고표체,후자가능통과림파관생성촉진림파결전이.
Objective To explore the relationship among VEGF-C and lymphangiogenesis,lymphatic metastasis in lung cancer.Methods 42 cases of nonsmall cell lung cancer diagnosed by thoracoscope surgery and pathology(lung cancer group) and 20 cases of lung benign diseases (control group) were collected.The patients underwent CT scan before surgery.Tumor tissue was immunohistochemically stained for VEGF-C,VEGFR-3.VEGF-C and LVD were compared in the 2 groups.The relationship between VEGF-C expression and lymph node metastasis in lung cancer group was evaluated.Results NSCLC Group had significant higher VEGF-C positive rate(69.0％ vs 5.0％,P＜ 0.01) and LVD level was significantly higher than that of control group[(11.67 ± 2.93) vs (3.81 ± 1.39),P ＜ 0.01)].CT signs of lymphatic metastasis demonstrated lymphangitis carcinomatosa,lymph node metastasis in lung hilum and mediastinal.Lymph-node-metastasis positive had a higher VEGF-C expression than negative(90％ vs 31.8％,P ＜ 0.01).Conclusion The high expression of VEGF-C may accelerate lymphatic metastasis in lung cancer by lymphangiogenesis.