CAJ | 학술논문

目的观察健脾祛痰汤合并喹硫平治疗精神分裂症阴性症状的疗效和不良反应.方法采用随机数字表,将60例精神分裂症患者分为治疗组(健脾祛痰汤合并喹硫平)和对照组(喹硫平).在治疗前、治疗第1、4、8周末以阳性和阴性症状量表(PANSS)总分减分率和不良反应量表(TESS)评定疗效和不良反应.结果两组总体疗效比较无显著性差异,治疗组阴性症状和激活性方面的改善较对照组明显(P＜0.05),且治疗组药物不良反应出现频率较对照组低,而凡轻微.结论健脾祛痰汤合并喹硫平治疗精神分裂症阴性症状的疗效显著,且可以减少精神科药物的用量,减少和缓解抗精神药物引起的副反应,同时改善患者的躯体情况,具有一定的安全性.
목적 관찰건비거담탕합병규류평치료정신분렬증음성증상적료효화불량반응.방법 채용수궤수자표,장60례정신분렬증환자분위치료조(건비거담탕합병규류평)화대조조(규류평).재치료전、치료제1、4、8주말이양성화음성증상량표(PANSS)총분감분솔화불량반응량표(TESS)평정료효화불량반응.결과 량조총체료효비교무현저성차이,치료조음성증상화격활성방면적개선교대조조명현(P＜0.05),차치료조약물불량반응출현빈솔교대조조저,이범경미.결론 건비거담탕합병규류평치료정신분렬증음성증상적료효현저,차가이감소정신과약물적용량,감소화완해항정신약물인기적부반응,동시개선환자적구체정황,구유일정적안전성.
Objective To observe the efficacy and side effects of Jianpi Qutan Decoction combined with Quetiapine in the treatment negative symptoms of schizophrenia.Methods 60 inpatients with schizophrenia were randomly divided into two groups,with one group treated with Jianpi Qutan Decoction combined Quetiapine and the other group treated with Quetiapine.Effects and side effects were assessed with the Positive and Negative Syndrome Scale (PANSS) and Treatment Emergent Symptoms Scale (TESS) respectively 1,4 and 8 weeks before and after the treatment.Results There was no significant difference in the overall efficacy between the two groups,but the improvement of the negative symptoms and illness provocation was significantly better in the treatment group than that in the control group respectively (P＜0.05).Moreover,the adverse reaction was milder in the treatment group.Conclusion It is suggested Jianpi Qutan Decoction in combination with typical antipsychotics is effective and safe in treating negative symptoms in schizophrenia patients.