CAJ | 학술논문

目的研究尿自然杀伤(NK)细胞含量与肾小球肾炎(GN)细胞增生程度的关系.方法用流式细胞仪(FCM)测定54例GN患者尿NK细胞含量,将肾活检结果按照是否存在细胞新月体、毛细血管内增殖分为急性增殖组30例与非急性增殖组24例,比较2组患者尿NK细胞含量.结果 30例急性增生性肾炎患者尿NK细胞含量为(14.8±3.3)%;24例非急性增生性肾炎患者尿NK细胞含量为(21.6±2.9)%,急性增生性肾炎患者尿NK细胞含量明显低于非急性增生性肾炎组(P<0.05).结论 NK细胞含量降低可作为间接反映GN细胞活动程度指标之一.
목적 연구뇨자연살상(NK)세포함량여신소구신염(GN)세포증생정도적관계.방법 용류식세포의(FCM)측정54례GN환자뇨NK세포함량,장신활검결과안조시부존재세포신월체、모세혈관내증식분위급성증식조30례여비급성증식조24례,비교2조환자뇨NK세포함량.결과 30례급성증생성신염환자뇨NK세포함량위(14.8±3.3)%;24례비급성증생성신염환자뇨NK세포함량위(21.6±2.9)%,급성증생성신염환자뇨NK세포함량명현저우비급성증생성신염조(P<0.05).결론 NK세포함량강저가작위간접반영GN세포활동정도지표지일.
Objective To evaluate the clinical significance of detecting urinary natural killer(NK) cells in patients with general types of glomerulonephritis. Methods The contents of urinary NK cells from 54 patients with glomerulonephritis were measured by flowcytometry,while all patients were classified into two groups including acute proliferation group and none-acute proliferation group by renal biopsy results. The content of urinary NK cells was compared between the two groups. Results The content of urinary NK cells in acute proliferative glomerular disease group were( 14. 8 ±3. 3)% (30 cases) ,which was significantly higher than that of(21. 6 ±2. 9)% (24 cases) in the non-acute proliferative glomerular patients(P<0.05). Conclusions Decreasing of the contents of NK cells in urine may be an indirect indicator of the activity of glomerulonephritis.