国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2011年
5期
355-359
,共5页
阻塞性睡眠呼吸暂停低通气综合征%睾酮%经鼻持续气道正压通气
阻塞性睡眠呼吸暫停低通氣綜閤徵%睪酮%經鼻持續氣道正壓通氣
조새성수면호흡잠정저통기종합정%고동%경비지속기도정압통기
Obstructive sleep apnea-hypopnea syndrome%Testosterone%Nasal continuous positive airway pressure
目的 研究福州城镇男性阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的血清睾酮水平及经鼻持续气道正压通气(nCPAP)治疗对OSAHS患者血清睾酮水平的影响.方法 182例入选者经多导睡眠监测,按年龄分25～45岁、46～65岁两层,再按睡眠呼吸紊乱严重程度进行分组:分别为正常对照组(20例、21例)、单纯性鼾症组(14例、13例)、轻度OSAHS组(21例、17例)、中度OSAHS组(19例、19例)、重度OSAHS组(18例、20例).在多导睡眠监测次晨抽取外周静脉血用电化学发光法测定血清睾酮.对比正常对照组、单纯性鼾症组、OSAHS组间睾酮水平的差异,分析睾酮水平与睡眠呼吸紊乱指数(AHI)、体质量指数(BMI)之间的相关性.开展nCPAP干预实验,对接受/未接受nCPAP治疗的中重度OSANS患者随访3个月,复查多导睡眠监测及血清睾酮指标.结果 ①正常对照组与单纯性鼾症组2组间血清睾酮差异无统计学意义(P值均＞0.05).OSAHS组血清睾酮较正常对照组及单纯性鼾症组低.②睾酮与AHI、BMI、年龄均呈负相关(r=-0.589,P＜0.01;r=-0.225;P＜0.05;r=-0.454,P＜0.01),睾酮与最低SaO2呈正相关(r=0.459,P＜0.01).③中重度OSAHS患者中,接受nCPAP治疗者随访3个月后,血清睾酮水平升高(P＜0.01).未接受nCPAP治疗者随访3个月后,血清睾酮水平无明显变化(P＞0.05).结论 ①OSAHS患者血清睾酮水平低,血清睾酮水平与AHI、BMI呈负相关.②OSAHS患者血清睾酮水平随年龄增加而降低.③nCPAP治疗可改善OSAHS患者血清睾酮水平.
目的 研究福州城鎮男性阻塞性睡眠呼吸暫停低通氣綜閤徵(OSAHS)患者的血清睪酮水平及經鼻持續氣道正壓通氣(nCPAP)治療對OSAHS患者血清睪酮水平的影響.方法 182例入選者經多導睡眠鑑測,按年齡分25～45歲、46～65歲兩層,再按睡眠呼吸紊亂嚴重程度進行分組:分彆為正常對照組(20例、21例)、單純性鼾癥組(14例、13例)、輕度OSAHS組(21例、17例)、中度OSAHS組(19例、19例)、重度OSAHS組(18例、20例).在多導睡眠鑑測次晨抽取外週靜脈血用電化學髮光法測定血清睪酮.對比正常對照組、單純性鼾癥組、OSAHS組間睪酮水平的差異,分析睪酮水平與睡眠呼吸紊亂指數(AHI)、體質量指數(BMI)之間的相關性.開展nCPAP榦預實驗,對接受/未接受nCPAP治療的中重度OSANS患者隨訪3箇月,複查多導睡眠鑑測及血清睪酮指標.結果 ①正常對照組與單純性鼾癥組2組間血清睪酮差異無統計學意義(P值均＞0.05).OSAHS組血清睪酮較正常對照組及單純性鼾癥組低.②睪酮與AHI、BMI、年齡均呈負相關(r=-0.589,P＜0.01;r=-0.225;P＜0.05;r=-0.454,P＜0.01),睪酮與最低SaO2呈正相關(r=0.459,P＜0.01).③中重度OSAHS患者中,接受nCPAP治療者隨訪3箇月後,血清睪酮水平升高(P＜0.01).未接受nCPAP治療者隨訪3箇月後,血清睪酮水平無明顯變化(P＞0.05).結論 ①OSAHS患者血清睪酮水平低,血清睪酮水平與AHI、BMI呈負相關.②OSAHS患者血清睪酮水平隨年齡增加而降低.③nCPAP治療可改善OSAHS患者血清睪酮水平.
목적 연구복주성진남성조새성수면호흡잠정저통기종합정(OSAHS)환자적혈청고동수평급경비지속기도정압통기(nCPAP)치료대OSAHS환자혈청고동수평적영향.방법 182례입선자경다도수면감측,안년령분25～45세、46～65세량층,재안수면호흡문란엄중정도진행분조:분별위정상대조조(20례、21례)、단순성한증조(14례、13례)、경도OSAHS조(21례、17례)、중도OSAHS조(19례、19례)、중도OSAHS조(18례、20례).재다도수면감측차신추취외주정맥혈용전화학발광법측정혈청고동.대비정상대조조、단순성한증조、OSAHS조간고동수평적차이,분석고동수평여수면호흡문란지수(AHI)、체질량지수(BMI)지간적상관성.개전nCPAP간예실험,대접수/미접수nCPAP치료적중중도OSANS환자수방3개월,복사다도수면감측급혈청고동지표.결과 ①정상대조조여단순성한증조2조간혈청고동차이무통계학의의(P치균＞0.05).OSAHS조혈청고동교정상대조조급단순성한증조저.②고동여AHI、BMI、년령균정부상관(r=-0.589,P＜0.01;r=-0.225;P＜0.05;r=-0.454,P＜0.01),고동여최저SaO2정정상관(r=0.459,P＜0.01).③중중도OSAHS환자중,접수nCPAP치료자수방3개월후,혈청고동수평승고(P＜0.01).미접수nCPAP치료자수방3개월후,혈청고동수평무명현변화(P＞0.05).결론 ①OSAHS환자혈청고동수평저,혈청고동수평여AHI、BMI정부상관.②OSAHS환자혈청고동수평수년령증가이강저.③nCPAP치료가개선OSAHS환자혈청고동수평.
Objective To explore the testosterone levels in Fuzhou urban male patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and impact of nasal continuous positive airway pressure (nCPAP) treatment. Methods Following polysomnographic examination, 182 sbjucts were assigned to 25-45years and 46-65years two groups. Each group consist of:control group(20,21 case), simple snores(14,13case), mild OSAHS(21,17case) ,moderate OSAHS(19,19 case),and severe OSAHS (18,20case). The serum level of testosterone was measured after sleep at the polysomnographic examination night. Of 76 patients with moderate or severe OSAHS, 29 patients who underwent nCPAP therapy were set as "nCPAP group" ,47 patients who did not undergo nCPAP therapy were set as "control group". 10 patients were excluded from further follow-up. The assessment protocol was then repeated after 3 months follow-up. Results ①There were no statistically significant differences of the serum level of testosterone between simple snores and control group. The serum level of testosterone was significantly lower in OSAHS patient. ② Liner regression analysis showed the serum level of testosterone was negatively correlated with AHI, BMI, year( r = -0.589, P ＜0. 01; r = -0.225, P ＜0.05; r = - 0.454, P＜0. 01), testosterone was correlated with SaO2 ( r =0.459, P ＜0.01). ③After 3 months nCPAP therapy in OSAHS patients, the serum level of testosterone was significantly increased ( P ＜ 0.01). While there were no similar changes in OSAHS patients without nCPAP therapy( P >0. 05). Conclusions ①OSAHS patients have lower level of testosterone. The serum level of testosterone was negatively correlated with AHI,BMI. ②As the age older,the serum level of testosterone lower in OSAHS patients. ③The serum level of testosterone could be improved by nCPAP therapy in OSAHS patients.
