CAJ | 학술논문

目的通过对972例结肠癌患者临床病理等因素的分析,探讨影响结肠癌患者术后生存的因素.方法对972例结肠癌患者的临床资料进行单因素及多因素COX回归分析,生存率采用寿命表法计算,生存率的比较采用Log.rank检验法.结果单因素分析表明,年龄、围手术期输血、术前血清cEA(癌胚抗原,carcinoembryonie aIltigen)水平、肿瘤大体类型、肿瘤浸润深度、淋巴结转移、肝转移、其他脏器转移、肿瘤局部复发、腹膜种植、病理类型、TNM分期及淋巴结廓清术式均为影响预后的因素.多因素回归分析表明,年龄、术前血清CEA水平、肿瘤大体类型、淋巴结转移、肝转移、其他脏器转移、肿瘤局部复发、腹膜种植、病理类型、淋巴结廓清术式以及TNM分期是影响患者术后生存的独立因素.结论淋巴结转移是影响结肠癌患者预后最重要的因素.
목적 통과대972례결장암환자림상병리등인소적분석,탐토영향결장암환자술후생존적인소.방법 대972례결장암환자적림상자료진행단인소급다인소COX회귀분석,생존솔채용수명표법계산,생존솔적비교채용Log.rank검험법.결과 단인소분석표명,년령、위수술기수혈、술전혈청cEA(암배항원,carcinoembryonie aIltigen)수평、종류대체류형、종류침윤심도、림파결전이、간전이、기타장기전이、종류국부복발、복막충식、병리류형、TNM분기급림파결곽청술식균위영향예후적인소.다인소회귀분석표명,년령、술전혈청CEA수평、종류대체류형、림파결전이、간전이、기타장기전이、종류국부복발、복막충식、병리류형、림파결곽청술식이급TNM분기시영향환자술후생존적독립인소.결론 림파결전이시영향결장암환자예후최중요적인소.
Objective To investigate the prognostic factots by analyzing clinicopathologlcal characteristics of 972 cases of colonic carcinoma. Methods Clinical and pathological data of 972 patients with colonic carcinoma treated surgically were studied by univariate and multivariate analysis,survival rate was calculated by life-table method and compared by Log-rank test. Results The univariate analysis indicated that the predictors of survival were age,perioperative blood transfusion, perioperative carcinoembryonic antigen(CEA)level,tumor gross type,depth of tumor invasion,lymphatic invasion,liver metastasis,extrahepatic metastasis,local recurrence、peritoneal seeding,pathological type,TNM stage and type of lymph node clearance.The multivariate analysis indicated that the independent predictors of suivival were age,periopemtive CEA level,tumor gross type,lymphatic invasion,liver metastasm,extrahepatic metastasis,local recurrence、peritioneal seeding,pathological type,type of lymph node clearance and TNM stage. Confclusions Lymphatic invasion is the most important independent prognostic factor of patients with colonic carcinoma treated surgically.