CAJ | 학술논문

目的检测下肢深静脉血栓形成的患者血浆中凝血因子Ⅷ(FⅧ)及蛋白C、蛋白S水平的变化,探讨其与深静脉血栓形成的关系.方法用ACL TOP型全自动血凝分析仪检测40例急件期深静脉血栓形成患者及40例健康体检者血浆中FⅧ及蛋白C、蛋白S的活性.结果与正常对照组比较,病例组患者体内FⅧ的活性明显增高,是深静脉血栓形成的危险因素,OR值为11.0,95%可信区间为3.3～36.7,排除蛋白C、蛋白S降低的影响,则OR值为5.4,95%可信区间为1.6～18.2.两组比较,病例组中蛋白C和蛋白S的活性明显降低,差异有统计学意义(P<0.05).结论深静脉血栓形成的患者体内FⅧ活性明显升高,而蛋白C及蛋白S的活性明显降低,凝血及抗凝系统的异常是深静脉血栓形成的高危因素之一.
목적 검측하지심정맥혈전형성적환자혈장중응혈인자Ⅷ(FⅧ)급단백C、단백S수평적변화,탐토기여심정맥혈전형성적관계.방법 용ACL TOP형전자동혈응분석의검측40례급건기심정맥혈전형성환자급40례건강체검자혈장중FⅧ급단백C、단백S적활성.결과 여정상대조조비교,병례조환자체내FⅧ적활성명현증고,시심정맥혈전형성적위험인소,OR치위11.0,95%가신구간위3.3～36.7,배제단백C、단백S강저적영향,칙OR치위5.4,95%가신구간위1.6～18.2.량조비교,병례조중단백C화단백S적활성명현강저,차이유통계학의의(P<0.05).결론 심정맥혈전형성적환자체내FⅧ활성명현승고,이단백C급단백S적활성명현강저,응혈급항응계통적이상시심정맥혈전형성적고위인소지일.
Objective To detect the activity of plasma factor Ⅷ, protein C, protein S in patients with lower deep venous thrombosis. Methods American IL automatic analyzer was used to detect the activity of factor Ⅷ, protein C and protein S in 40 patients with deep venous thrombosis and 40 normal controls. Results The plasma level of factor Ⅷ was statistically significantly higher in the study group than in the control group ( P < 0. 05 ). Factor Ⅷ was associated with an increased risk of venous thrombosis with the relative risk being 11. 0 (95% CI, 3.3-36. 7). Excluding the patients with reduced protein C and protein S levels, the relative risk was dropped to 5.4 (95% CI, 1.6-18.2). There also were significant differences in the activity of protein C, protein S between the study group and the normal control group ( P < 0. 05 ). Conclusion The activity of factor Ⅷ in patients with deep venous thrombosis is increased significantly, and the activity of protein C, protein S decreased obviously. All of those are risk factors for deep venous thrombosis.