CAJ | 학술논문

目的探讨乙肝型肝炎病毒(HBV.)DNA阳性孕妇胎儿宫内HBV感染和母乳HBV传播.方法应用荧光定量聚合酶链反应(FQ-PCR)对92例HBV DNA阳性孕妇血中病毒含量及其产后初乳和新生儿脐血中HBV DNA的含量进行定量检测.结果92例新生儿有55例HBV DNA阳性,胎儿宫内HBV感染率为59.8%;92例母乳有59例HBV DNA阳性,即59例有HBV排出,排毒率64.1%;母血中平均HBV DNA的含量(拷贝数/ml的对数)为(7.15±1.87),显著高于脐血、初乳中HBV DNA的含量:(6.005±1.23)和(5.04±0.83);胎儿宫内感染率,母乳排毒率,随孕妇血中HBV DNA含量增加而增加;母血HBV DNA含量与55例阳性脐血、59例阳性母乳HBV DNA含量呈正相关(r=0.43、0.32).结论孕妇血中HBV DNA高含量是胎儿宫内HBV感染的高危因素;HBV DNA阳性孕妇的母乳大多数具有低水平传染性,采取适当措施,可谨慎哺乳.
목적탐토을간형간염병독(HBV.)DNA양성잉부태인궁내HBV감염화모유HBV전파.방법응용형광정량취합매련반응(FQ-PCR)대92례HBV DNA양성잉부혈중병독함량급기산후초유화신생인제혈중HBV DNA적함량진행정량검측.결과92례신생인유55례HBV DNA양성,태인궁내HBV감염솔위59.8%;92례모유유59례HBV DNA양성,즉59례유HBV배출,배독솔64.1%;모혈중평균HBV DNA적함량(고패수/ml적대수)위(7.15±1.87),현저고우제혈、초유중HBV DNA적함량:(6.005±1.23)화(5.04±0.83);태인궁내감염솔,모유배독솔,수잉부혈중HBV DNA함량증가이증가;모혈HBV DNA함량여55례양성제혈、59례양성모유HBV DNA함량정정상관(r=0.43、0.32).결론잉부혈중HBV DNA고함량시태인궁내HBV감염적고위인소;HBV DNA양성잉부적모유대다수구유저수평전염성,채취괄당조시,가근신포유.
Objective:To investigate the intrauterine infection of newborns and HBV transmission by breast niilk of pregenant women with HBV DNA positivity.Methods:HBV DNA in blood samples of 92 HBV DNA positive pregenant women,breast milk samples and cord blood of their newborns was detected by FQ-PCR.Results:92 cord blood had 55 HBV DNA positivity,the fetal intrauterine inffectious rate was 59.8% ,92 breast milk had 59 HBV DNA positivity,its outletting rate was 64.1%(59/92).The average concentration of serum HBV DNA in 92 pregenant women was(7.15 ± 1.87),which was significantly higher than that of cord blood and breast milk:[(5.05 ± 1.23)and(5.04 ± 0.83)].Intrauterine infectious rate and breast nilk outletting rate increased significantly when HBV DNA level increased in blood of pregnant women,and their concerntrations of HBV DNA were positively correlated to that of mother blood(r = 0.43,0.32).Conclusions:High HBV DNA load of pregnant women is one of high risk factors of fetal intrauterine infection.Most of the breast milk with positive HBV DNA has lower infection,newborn infants can be cautiously given breast feeding after taking proper measure.