CAJ | 학술논문

目的:观察依达拉奉对急性脑梗死患者血清IL-17、IL-6和TNF-α的影响.方法:选择发病24 h内的急性脑梗死患者63例,随机分为依达拉奉组和对照组,对照组31例按急性脑梗死常规方法治疗2周,依达拉奉组32例在常规治疗基础上加用依达拉奉治疗2周,治疗前、治疗后7 d、14 d检测患者血清IL-17、IL-6和TNF-α.结果:两组患者治疗前及治疗7 d IL-17、IL-6、TNF-α水平无统计学差异,但治疗14 d依达拉奉组各项指标均低于对照组,差异有统计学意义.两组患者治疗7d和14 d IL-17、IL-6、INF-α水平均低于治疗前,差异有统计学意义.结论:依达拉奉能显著降低急性脑梗死患者血清炎症因子IL-17、IL-6和TNF-α的水平,这可能是其治疗脑梗死的机制之一.
목적:관찰의체랍봉대급성뇌경사환자혈청IL-17、IL-6화TNF-α적영향.방법:선택발병24 h내적급성뇌경사환자63례,수궤분위의체랍봉조화대조조,대조조31례안급성뇌경사상규방법치료2주,의체랍봉조32례재상규치료기출상가용의체랍봉치료2주,치료전、치료후7 d、14 d검측환자혈청IL-17、IL-6화TNF-α.결과:량조환자치료전급치료7 d IL-17、IL-6、TNF-α수평무통계학차이,단치료14 d의체랍봉조각항지표균저우대조조,차이유통계학의의.량조환자치료7d화14 d IL-17、IL-6、INF-α수평균저우치료전,차이유통계학의의.결론:의체랍봉능현저강저급성뇌경사환자혈청염증인자IL-17、IL-6화TNF-α적수평,저가능시기치료뇌경사적궤제지일.
Objective:To study effects of edaravone on the levels of serum intedeukin-17 (IL-17),IL-6,tumor necrosis factor-α (TNF-α) in patients with acute cerebral infarction.Methods:63 patients of cerebral infarction were randomly divided and assigned to edaravone group and control group.31 patients in control group were treated by routine therapy of acute cerebral infarction two weeks.Another 32 patients in edaravone group were treated with routine therapy and edaravone for two weeks.The levels of serum IL-17,IL-6,and TNF-α were measured by enzyme-linked immunusorbent assay before treatment and after treatment 7d and 14d.Results:Although there were no difference before treatment and after treatment 7d,the levels of serum IL-17,IL-6,and TNF-α were found to be sharply decreased in edaravone group compared with the control group after treatment 14d.The levels of serum IL-17,IL-6,and TNF-α in two groups were lower significantly after treatment 7d and 14d than before treatment.Conclusions:Edaravone can decrease the levels of serum IL-17,IL-6,and TNF-α,which probably reduce the injury of ischemic brain and improve therapeutic efficacy.