CAJ | 학술논문

目的:观察声门癌及癌旁组织中SKP2及MRP-1/CD9蛋白的变化意义及其对声门癌手术安全切除范围的指导意义.方法:用免疫组织化学SP法检测38例声门鳞状细胞癌组织及距癌组织边缘2、5、10 mm的组织中SKP2及MRP-1/CD9蛋白的表达,并取10例声带息肉组织作对照.结果:SKP2蛋白产物异常表达按息肉黏膜组织、癌旁组织(2、5、10 mm) 及癌组织的顺序依次递减, 差异有统计学意义(均P<0.05); MRP-1/CD9蛋白产物异常表达按息肉黏膜组织、癌旁组织(2、5、10 mm ) 及癌组织的顺序依次递增, 差异有统计学意义(均P<0.05).结论:SKP2及MRP-1/CD9均可作为判断喉癌生物学特性的参考指标,声门癌手术安全切缘以距肿瘤≥5 mm的标准较为适宜.
목적:관찰성문암급암방조직중SKP2급MRP-1/CD9단백적변화의의급기대성문암수술안전절제범위적지도의의.방법:용면역조직화학SP법검측38례성문린상세포암조직급거암조직변연2、5、10 mm적조직중SKP2급MRP-1/CD9단백적표체,병취10례성대식육조직작대조.결과:SKP2단백산물이상표체안식육점막조직、암방조직(2、5、10 mm) 급암조직적순서의차체감, 차이유통계학의의(균P<0.05); MRP-1/CD9단백산물이상표체안식육점막조직、암방조직(2、5、10 mm ) 급암조직적순서의차체증, 차이유통계학의의(균P<0.05).결론:SKP2급MRP-1/CD9균가작위판단후암생물학특성적삼고지표,성문암수술안전절연이거종류≥5 mm적표준교위괄의.
Objective:To study the expression of SKP2 and MRP-1/CD9 protein in glottic cancer and adjacent tissues,and to analyze its significance for a safe surgical margin.Method:Thirty-eight cases of glottic squamous cell carcinoma were studied for its cancer tissue, tissue 2 mm, 5 mm , and 10 mm away from cancer ,and 10 cases of vocal cord polyp were served as control. SKP2 and MRP-1/CD9 protein were examined by immunoh istochemical method.Result:The positive expression of SKP2 proteins decreased in sequence of polyp mucosa, those adjacent to carcinoma (10 mm, 5 mm, 2 mm ) and cancer tissue, and there was significant difference between them(P<0.05);On the contrary, the positive expression of the MRP-1/CD9 proteins increased in sequence of polypusmucosa, those adjacent to carcinoma (10 mm,5 mm, 2 mm) and cancer tissue,and there was significant difference between them (P<0.05).Conclusion:SKP2 and MRP-1/CD may act as the reference index for judging the biological speciality of LSCC. It is appropriate to regard 5 mm or above 5 mm away from tumors as a safe margin for surgical treatment of glottic carcinoma.