中国医药
中國醫藥
중국의약
CHINA MEDICINE
2012年
11期
1409-1411
,共3页
林俊东%徐建成%郑亚明%洪嘉志%林乔龄
林俊東%徐建成%鄭亞明%洪嘉誌%林喬齡
림준동%서건성%정아명%홍가지%림교령
银杏叶提取物%股骨头缺血性坏死%血管造影%介入治疗
銀杏葉提取物%股骨頭缺血性壞死%血管造影%介入治療
은행협제취물%고골두결혈성배사%혈관조영%개입치료
Ginkgo biloba extract%Avascular necrosis of the femoral head%Angiography%Interventional therapy
目的 观察经导管灌注银杏叶提取物治疗早期股骨头缺血性坏死(ANFH)的疗效,探讨其作用机制.方法 选择ANFH病例74例,完全随机分为治疗组(43例)和对照组(31例).治疗组给予银杏叶提取物注射液40ml,对照组予以丹参注射液40ml,分别加入右旋糖酐150 ml、罂粟碱30 mg、尿激酶30万U、山莨菪碱20 mg,混合液灌注股骨头滋养血管,比较2组患者的疗效及治疗前后的滋养血管、骨质的影像学改变.结果 治疗组43例中痊愈13例、显效19例、有效11例,总有效率100.0％；对照组31例中痊愈6例、显效9例、有效13例,总有效率90.3％；治疗组总有效率明显高于对照组,差异有统计学意义(P＜0.05).结论 经导管灌注银杏叶提取物治疗ANFH安全有效,值得临床推广.
目的 觀察經導管灌註銀杏葉提取物治療早期股骨頭缺血性壞死(ANFH)的療效,探討其作用機製.方法 選擇ANFH病例74例,完全隨機分為治療組(43例)和對照組(31例).治療組給予銀杏葉提取物註射液40ml,對照組予以丹參註射液40ml,分彆加入右鏇糖酐150 ml、罌粟堿30 mg、尿激酶30萬U、山莨菪堿20 mg,混閤液灌註股骨頭滋養血管,比較2組患者的療效及治療前後的滋養血管、骨質的影像學改變.結果 治療組43例中痊愈13例、顯效19例、有效11例,總有效率100.0％；對照組31例中痊愈6例、顯效9例、有效13例,總有效率90.3％；治療組總有效率明顯高于對照組,差異有統計學意義(P＜0.05).結論 經導管灌註銀杏葉提取物治療ANFH安全有效,值得臨床推廣.
목적 관찰경도관관주은행협제취물치료조기고골두결혈성배사(ANFH)적료효,탐토기작용궤제.방법 선택ANFH병례74례,완전수궤분위치료조(43례)화대조조(31례).치료조급여은행협제취물주사액40ml,대조조여이단삼주사액40ml,분별가입우선당항150 ml、앵속감30 mg、뇨격매30만U、산랑탕감20 mg,혼합액관주고골두자양혈관,비교2조환자적료효급치료전후적자양혈관、골질적영상학개변.결과 치료조43례중전유13례、현효19례、유효11례,총유효솔100.0％；대조조31례중전유6례、현효9례、유효13례,총유효솔90.3％；치료조총유효솔명현고우대조조,차이유통계학의의(P＜0.05).결론 경도관관주은행협제취물치료ANFH안전유효,치득림상추엄.
Objective To observe the clinical efficacy of Ginkgo biloba extract (GBE) with transcatheter treatment for early avascular necrosis of the femoral head (ANFH) and to investigate the mechanism.Methods The patients with early ANFH (n =74) were randomly divided into the treatment group(n =43) treated with GBE injection and control group(n =31) treated with Danshen injection.Papaverine,urokinase,654-2 and low molecular weight dextran were injected directly into the arteries supplying the femoral head.The clinical data,including clinical symptoms,angiography and the change of bone was collected for evaluating the efficacy of treatment.Results Compared with the treatment group,no significant difference in the angiography of arteries of the femoral heads and short term efficacy was found in the control group(P ＞ 0.05) after interventional therapy.However,the improvement of bone in the images and long term efficacy were recorded in the treatment group(P ＜ 0.05) after the treatment.Conclusion Transcatheter intra-arterial infusion with GBE is safe and effective for the treatment of early ANFH.
