CAJ | 학술논문

蛋白C系统在人体凝血-抗凝反应的调控中发挥关键作用,是人体的重要抗凝系统之一.文章综述了蛋白C系统各组分的生化结构、生理功能及其基因变异的研究进展,在DNA水平上揭示了蛋白C系统遗传多态性对血栓性疾病发生、发展和转归的影响,对血栓性疾病的预防和个体化治疗具有重要的意义.
단백C계통재인체응혈-항응반응적조공중발휘관건작용,시인체적중요항응계통지일.문장종술료단백C계통각조분적생화결구、생리공능급기기인변이적연구진전,재DNA수평상게시료단백C계통유전다태성대혈전성질병발생、발전화전귀적영향,대혈전성질병적예방화개체화치료구유중요적의의.
Protein C system is one of the most primary anticoagulation system, which plays an important role in the interaction of coagulationanticoagulation reaction. The article reviews protein C system, to provide an overview of the biochemical structures, physiologic functions and genovariations of its constituents, based on the new findings in resent years. It reveals, on the DNA level, the influence of occurrence, development and sequelae of thromboembolic disease, which genetic polymorphisms of protein C system affect on. It is of great significance in the prevention of thromboembolic diseases and individualized treatments.