CAJ | 학술논문

目的探讨异基因造血干细胞移植(allo-HSCT)前后恶性血液病患者染色体核型的变化规律及其在allo-HSCT预后监测中的意义.方法回顾性分析21例allo-HSCT后复发的恶性血液病患者初诊和复发时的染色体核型资料,并结合临床进行相关性分析.染色体检查采用24 h短期培养R显带技术.结果 21例恶性血液病患者中11例(52.38%)患者allo-HSCT后复发时染色体核型发生改变,多见于1、3、6、12、17、21号等染色体,而且染色体数目和结构异常多同时出现.移植复发时染色体核型出现改变的患者移植复发中位生存时间显著短于未出现改变的患者(79 d 对522 d,P=0.027).出现6号染色体三体的患者比未出现该改变患者的移植复发中位生存时间明显缩短(9 d 对 275 d,P=0.005).结论 allo-HSCT后患者复发时染色体核型的改变与预后有关.
목적 탐토이기인조혈간세포이식(allo-HSCT)전후악성혈액병환자염색체핵형적변화규률급기재allo-HSCT예후감측중적의의.방법 회고성분석21례allo-HSCT후복발적악성혈액병환자초진화복발시적염색체핵형자료,병결합림상진행상관성분석.염색체검사채용24 h단기배양R현대기술.결과 21례악성혈액병환자중11례(52.38%)환자allo-HSCT후복발시염색체핵형발생개변,다견우1、3、6、12、17、21호등염색체,이차염색체수목화결구이상다동시출현.이식복발시염색체핵형출현개변적환자이식복발중위생존시간현저단우미출현개변적환자(79 d 대522 d,P=0.027).출현6호염색체삼체적환자비미출현해개변환자적이식복발중위생존시간명현축단(9 d 대 275 d,P=0.005).결론 allo-HSCT후환자복발시염색체핵형적개변여예후유관.
Objective To analyze the karotype stablity in hematological malignancies patients before and after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and its prognostic significance of monitoring. Methods The karotypes and clinical data of 21 patients with hematological malignancies at the initial diagnosis and at relapse after allo-HSCT were retrospectively reviewed. Choromosome analysis was performed by standard 24 h-cultured method and R banding. Results Karotypes at the initial diagnosis and at relapse after allo-HSCT were different in 11 patients (52.38%),including chromosome 1,3,6,12,17,21. Numberical abnormalities and structural chromosomal abnormalities always occurs together. The median survival time of relapse of the patients with karytope changes was significantly shorter than that of patients without a karyotype change(79 d vs 522 d, P=0.027), and that of the patients with trisomy 6 was also significantly shorter than that of the patients without trisomy 6(9 d vs 275 d, P=0.005). Conclusion Karotype changes after relapse are associated with the progosis of allo-HSCT.