CAJ | 학술논문

为了调查山西省阳泉市等地区食管癌高发病率的原因并探讨家族中有食管癌史的对食管癌发病率的影响.我们以原卟啉作为癌瘤的分子标志物,建立了通过血清荧光的检测进行恶性肿瘤诊断的方法,开展了食管癌流行病学调查.采用双盲法对10位已确诊为食管癌的患者及其56户有血缘关系的亲属共316人进行了血清荧光检测.查出56例阳性,其中包括10位食管癌患者,对其余46人进行了胃镜检查,未发现癌症,待继续随访查证.在普查过程中我们观察到,阳性例出现在40年-70年龄段的占阳性例的80%;阳性例出现在15户人家,5口人之家出现2例阳性的有3户,10口人之家出现3例阳性的有1户,10位食管癌患者的家庭出现2例阳性的有3户,呈现出家系性.
위료조사산서성양천시등지구식관암고발병솔적원인병탐토가족중유식관암사적대식관암발병솔적영향.아문이원계람작위암류적분자표지물,건립료통과혈청형광적검측진행악성종류진단적방법,개전료식관암류행병학조사.채용쌍맹법대10위이학진위식관암적환자급기56호유혈연관계적친속공316인진행료혈청형광검측.사출56례양성,기중포괄10위식관암환자,대기여46인진행료위경검사,미발현암증,대계속수방사증.재보사과정중아문관찰도,양성례출현재40년-70년령단적점양성례적80%;양성례출현재15호인가,5구인지가출현2례양성적유3호,10구인지가출현3례양성적유1호,10위식관암환자적가정출현2례양성적유3호,정현출가계성.
In order to investigate the causes of the high incidence of esophagus cancer around the region of Yangquan in Shanxi province and probe into the influence from the kindred disease history, a fluorescence spectral diagnostic method was established using protoporphyrin IX as the index molecule. In this method, the fluorescence spectrum of the serum was analyzed to diagnose the malignant tumors. With this method, a survey of esophagus cancer had been made to 316 people with 10 cancer patients and all the others from the kindred families of the patients. Each spectrum was analyzed without knowing whom it belongs to. And 56 spectra showed the positive results. It turned out that the spectra obtained from the 10 patients' sero all showed positive results.The other 46 positive results need further investigation to be verified in the subsequent years. Among these positive results, 80% of them came from the people aged between 40 to 70. All the positive results came from 15 families, and 2 out of 5 members had positive results in 3 families, 3 out of 10 members had positive results in one family. Among the 10 patients' families, 3 of them had two members with positive results. The result appears the household feature.