临床心血管病杂志
臨床心血管病雜誌
림상심혈관병잡지
JOURNAL OF CLINICAL CARDIOLOGY
2009年
11期
814-817
,共4页
急性冠状动脉综合征%纤维蛋白原样蛋白2%外周血单个核细胞
急性冠狀動脈綜閤徵%纖維蛋白原樣蛋白2%外週血單箇覈細胞
급성관상동맥종합정%섬유단백원양단백2%외주혈단개핵세포
acute coronary syndrome%fibrinogen-like protein2%peripheral blood mononuclear cell
目的:探讨纤维蛋白原样蛋白2(fgl2)在急性冠状动脉综合征(ACS)患者外周血单个核细胞中的表达及其意义.方法:用荧光定量PCR法检测60例ACS、25例稳定型心绞痛(SA)患者和20例正常人外周血中单个核细胞中fgl2的表达量水平.结果:ACS组fgl2基因表达明显高于SA组和正常对照组(均P<0.05),SA组与正常对照组比较差异无统计学意义(P>0.05).结论:ACS患者急性期外周血单个核细胞中fgl2的表达明显增加, 可能是ACS微循环障碍有预测价值的急性时相性蛋白之一.
目的:探討纖維蛋白原樣蛋白2(fgl2)在急性冠狀動脈綜閤徵(ACS)患者外週血單箇覈細胞中的錶達及其意義.方法:用熒光定量PCR法檢測60例ACS、25例穩定型心絞痛(SA)患者和20例正常人外週血中單箇覈細胞中fgl2的錶達量水平.結果:ACS組fgl2基因錶達明顯高于SA組和正常對照組(均P<0.05),SA組與正常對照組比較差異無統計學意義(P>0.05).結論:ACS患者急性期外週血單箇覈細胞中fgl2的錶達明顯增加, 可能是ACS微循環障礙有預測價值的急性時相性蛋白之一.
목적:탐토섬유단백원양단백2(fgl2)재급성관상동맥종합정(ACS)환자외주혈단개핵세포중적표체급기의의.방법:용형광정량PCR법검측60례ACS、25례은정형심교통(SA)환자화20례정상인외주혈중단개핵세포중fgl2적표체량수평.결과:ACS조fgl2기인표체명현고우SA조화정상대조조(균P<0.05),SA조여정상대조조비교차이무통계학의의(P>0.05).결론:ACS환자급성기외주혈단개핵세포중fgl2적표체명현증가, 가능시ACS미순배장애유예측개치적급성시상성단백지일.
Objective:To investigate the expression and significance of fibrinogen-like protein 2(fgl2 ) prothrombinase in peripheral blood mononuclear cell (PBMC) of acute coronary syndrome (ACS) patients. Method:Fluorescence quantitative PCR was applied to detecting the expression of fgl2 in 60 ACS patients, 25 stable angina pectoris (SAP) patients and 20 normal people (CG).Result:The gene expression of fgl2 was significantly increased in ACS than SAP and CG (P<0.05), but there was no difference between SAP and CG (P>0.05). Conclusion:The gene expression of fgl2 of PBMC is increased in ACS patients at acute stage. It maybe a forecasting protein of acute phase in coronary artery disease especially ACS microcirculation disturbance.
