CAJ | 학술논문

目的应用Meta分析方法探讨中国人群HLA-DR基因多态性与肺结核易感性的关系.方法通过全面检索查找已发表的有关中国人群肺结核与HLA-DR基因关联性的文献.以肺结核组和健康对照组的HLA-DR等位基凼型频数分布的比值比为统计量,采用RevMan 5.0.13进行Meta分析.结果符合纳入标准的文献共7篇.Meta分析及敏感性分析发现.病例组和对照组DR4、DR16、DRB1*15和DRB1*13.2的合并比值比及其95%可信区间分别为1.64(1.08,2.50)、2.08(1.32,3.28)、2.94(1.34,6.49)和0.32(0.14,0.72).结论 DR4和DR16可能是南方汉族人群的易感基因;DRB1*15可能是北方汉族人群肺结核的易感基因,DRB1*13.2可能是其保护基因.
목적 응용Meta분석방법탐토중국인군HLA-DR기인다태성여폐결핵역감성적관계.방법 통과전면검색사조이발표적유관중국인군폐결핵여HLA-DR기인관련성적문헌.이폐결핵조화건강대조조적HLA-DR등위기당형빈수분포적비치비위통계량,채용RevMan 5.0.13진행Meta분석.결과 부합납입표준적문헌공7편.Meta분석급민감성분석발현.병례조화대조조DR4、DR16、DRB1*15화DRB1*13.2적합병비치비급기95%가신구간분별위1.64(1.08,2.50)、2.08(1.32,3.28)、2.94(1.34,6.49)화0.32(0.14,0.72).결론 DR4화DR16가능시남방한족인군적역감기인;DRB1*15가능시북방한족인군폐결핵적역감기인,DRB1*13.2가능시기보호기인.
Objective To evaluate the association between gene of HLA-DR and pulmonary tuberculosis in Chinese population by meta-analysis method. Methods Electronic searches were conducted roundly to find literatures about the relationship between pulmonary tuberculosis in Chinese population and HLA-DR. We analyzed odds ratios (OR) of HLA-DR genotype distributions in pulmonary tuberculosis patients against healthy controls by RevMan 5.0.13. Results 7 studies that met the eligibility criteria were involved. The results of meta-analysis and sensitivity analysis were the pooled OR (95% CI) of DR4, DR16, DRB1*15 and DRB1*13.2 in case and control group were 1.64(1.08, 2.50), 2.08(1.32,3.28), 2.94(1.34,6.49) and 0.32(0.14,0.72) respectively. Conclusions For Chinese southward population, DR4 and DR 16 can be regarded as susceptive gene of pulmonary tuberculosis. For Chinese northward population, DRB1 * 15 can be regarded as susceptible gene of pulmonary tuberculosis and DRB1 * 13.2 may be protective gene.