CAJ | 학술논문

　　复方口服避孕药（combined oral contraceptives，COCs）是目前甾体激素控制生育的主要方法。半个世纪以来，国内外的学者们不断地研制出更安全、可靠、有效的COCs，其主要成分雌激素在化学组成上更是经历了发展变化。综述现代COCs的早期开发和雌激素的发展进程。阐述炔雌醇和美雌醇2种雌激素的避孕机制。目前COCs中雌激素的主要研究方向是降低其剂量，使人体对药物的敏感性和依从性达到一个最适效应浓度，同时也在寻找一种比炔雌醇更优越的雌激素。
　　복방구복피잉약（combined oral contraceptives，COCs）시목전치체격소공제생육적주요방법。반개세기이래，국내외적학자문불단지연제출경안전、가고、유효적COCs，기주요성분자격소재화학조성상경시경력료발전변화。종술현대COCs적조기개발화자격소적발전진정。천술결자순화미자순2충자격소적피잉궤제。목전COCs중자격소적주요연구방향시강저기제량，사인체대약물적민감성화의종성체도일개최괄효응농도，동시야재심조일충비결자순경우월적자격소。
The combined oral contraceptives (COCs) are the main methods with steroidal hormones for birth control at present. For half a century,the more safe,reliable and effective COCs were continuously developed. The chemical composition of estrogen in COCs have also been improved. This article summarized the early process of modern COCs and the development of estrogen,as well as the contraceptive mechanism of ethinylestradiol and mestranol. The two developing areas of estrogen in COCs are as follows:to reduce its dose to achieve an optimal concentration for the body′s sensitivity and compliance,to find some better estrogens than ethinyl estradiol.