CAJ | 학술논문

目的通过对氢化泼尼松微胶囊缓释剂进行体外模拟释放试验,了解微胶囊延长药物释放的作用.方法用高效液相色谱(HPLC)法检测药物降解结果,同时用显微镜及电镜观察微胶囊降解过程.结果释放试验开始的12～24 h时,释放出药物量很低.随着微胶囊囊壁材料与PBS溶液接触时间延长(24～48h),并开始降解,释放的药物浓度也随着上升,在不同pH的PBS溶液中,由开始释放到达最高浓度一般需要3～5 d并维持数天释放.结论氢化泼尼松微胶囊缓释剂可有效延长包裹药物释放时间.
목적 통과대경화발니송미효낭완석제진행체외모의석방시험,료해미효낭연장약물석방적작용.방법 용고효액상색보(HPLC)법검측약물강해결과,동시용현미경급전경관찰미효낭강해과정.결과 석방시험개시적12～24 h시,석방출약물량흔저.수착미효낭낭벽재료여PBS용액접촉시간연장(24～48h),병개시강해,석방적약물농도야수착상승,재불동pH적PBS용액중,유개시석방도체최고농도일반수요3～5 d병유지수천석방.결론 경화발니송미효낭완석제가유효연장포과약물석방시간.
Objective By extra-body imitation release test with prolongation,medicines action on sustainedreleased injection of hydro-cortisone microeapsule was understood. Methods Making use of HPLC method was inspected to result of medicinal lower and die, solution. At the same time, the disaolvent course of microcapsule wall was observed by microscope and electron microscope. Results The release test at beginning 12 - 24 hours with rdease drugs measure was very lower-degree,along with the time more prolong in mierocapsule substance to contact of PBS solution(24～48h) was began disintegrate. The rdease of medicinal concentration also accompany with rising, the rising different concentration PBS solution from starting up to the highest as to general need 3～5 days and keep releasing for several days. Conclusion Sustained-released injection of hydrocortisone mierocapsule can be effectual action of prolongation released time in hind hydrocortisone.