中国地方病学杂志
中國地方病學雜誌
중국지방병학잡지
CHINESE JOURNAL OF ENDEMIOLOGY
2008年
5期
532-534
,共3页
裴俊瑞%王宇%李兴洲%高琳%闫丽佳%李奇%侯杰%周令望%张立君%陈洁%张辉%王铜
裴俊瑞%王宇%李興洲%高琳%閆麗佳%李奇%侯傑%週令望%張立君%陳潔%張輝%王銅
배준서%왕우%리흥주%고림%염려가%리기%후걸%주령망%장립군%진길%장휘%왕동
克山病%硒%肠道病毒B型,人
剋山病%硒%腸道病毒B型,人
극산병%서%장도병독B형,인
Keshan disease(KD)%Selenium%Enterovinls B.Human
目的 了解黑龙江省克山病病区内外环境硒水平及柯萨奇B组病毒(CVB)人群感染情况,为采取有针对性的防治措施提供依据.方法 在克山病病区设立病区病例组和病区对照组,在非病区设立非病区对照组,采集血液样品用于检测血硒及CVB IgM抗体,同时采集病区和非病区土壤、粮食用于硒测定;硒的测定采用氢化物发生原子荧光光度法.CVB IgM抗体采用酶联免疫吸附法(ELISA)检测.结果 病区土壤、玉米、小麦、大豆含硒量[(0.092±0.011)、(0.003±0.001)、(0.005±0.003)、(0.006±0.001)mg/kg]均低于非病区[(0.198±0.016)、(0.012±0.004)、(0.037±0.007)、(0.037±0.008)mg/kg],二者比较差异均有统计学意义(t值分别为17.007、8.551、15.842、12.109,P<0.01).病区病例组血硒[(34.803±13.302)μg/L]低于病区对照组[(41.235 ±13.571)μg/L],二者比较差异有统计学意义(P<0.05);病区病例组、病区对照组、非病区对照组的CVB感染阳性率分别为90.0%(36/40)、68.3%(41/46)、45.8%(22/48),病区和非病区CVB感染的比值比(OR)为3.957,95%可信区间为1.898～8.246;病区病例组和病区对照组CVB感染的OR值为4.171,95%可信区间为1.298～13.404;CVB感染组与未感染组血硒水平比较,差异无统计学意义(t=1.179,P>0.05).结论 黑龙江省克山病病区仍存在低硒及CVB感染情况.
目的 瞭解黑龍江省剋山病病區內外環境硒水平及柯薩奇B組病毒(CVB)人群感染情況,為採取有針對性的防治措施提供依據.方法 在剋山病病區設立病區病例組和病區對照組,在非病區設立非病區對照組,採集血液樣品用于檢測血硒及CVB IgM抗體,同時採集病區和非病區土壤、糧食用于硒測定;硒的測定採用氫化物髮生原子熒光光度法.CVB IgM抗體採用酶聯免疫吸附法(ELISA)檢測.結果 病區土壤、玉米、小麥、大豆含硒量[(0.092±0.011)、(0.003±0.001)、(0.005±0.003)、(0.006±0.001)mg/kg]均低于非病區[(0.198±0.016)、(0.012±0.004)、(0.037±0.007)、(0.037±0.008)mg/kg],二者比較差異均有統計學意義(t值分彆為17.007、8.551、15.842、12.109,P<0.01).病區病例組血硒[(34.803±13.302)μg/L]低于病區對照組[(41.235 ±13.571)μg/L],二者比較差異有統計學意義(P<0.05);病區病例組、病區對照組、非病區對照組的CVB感染暘性率分彆為90.0%(36/40)、68.3%(41/46)、45.8%(22/48),病區和非病區CVB感染的比值比(OR)為3.957,95%可信區間為1.898～8.246;病區病例組和病區對照組CVB感染的OR值為4.171,95%可信區間為1.298～13.404;CVB感染組與未感染組血硒水平比較,差異無統計學意義(t=1.179,P>0.05).結論 黑龍江省剋山病病區仍存在低硒及CVB感染情況.
목적 료해흑룡강성극산병병구내외배경서수평급가살기B조병독(CVB)인군감염정황,위채취유침대성적방치조시제공의거.방법 재극산병병구설립병구병례조화병구대조조,재비병구설립비병구대조조,채집혈액양품용우검측혈서급CVB IgM항체,동시채집병구화비병구토양、양식용우서측정;서적측정채용경화물발생원자형광광도법.CVB IgM항체채용매련면역흡부법(ELISA)검측.결과 병구토양、옥미、소맥、대두함서량[(0.092±0.011)、(0.003±0.001)、(0.005±0.003)、(0.006±0.001)mg/kg]균저우비병구[(0.198±0.016)、(0.012±0.004)、(0.037±0.007)、(0.037±0.008)mg/kg],이자비교차이균유통계학의의(t치분별위17.007、8.551、15.842、12.109,P<0.01).병구병례조혈서[(34.803±13.302)μg/L]저우병구대조조[(41.235 ±13.571)μg/L],이자비교차이유통계학의의(P<0.05);병구병례조、병구대조조、비병구대조조적CVB감염양성솔분별위90.0%(36/40)、68.3%(41/46)、45.8%(22/48),병구화비병구CVB감염적비치비(OR)위3.957,95%가신구간위1.898～8.246;병구병례조화병구대조조CVB감염적OR치위4.171,95%가신구간위1.298～13.404;CVB감염조여미감염조혈서수평비교,차이무통계학의의(t=1.179,P>0.05).결론 흑룡강성극산병병구잉존재저서급CVB감염정황.
Objective To acquaint the situation of selenium nutrition level and coxsakievirus B(CVB) infection in Keshan disease(KD)patients in Heilongjiang province,and provide the evidence for taking the direction mell811rement$of KD contr01.Methods The subjeets were divided into three groups:disease area KD group, disease area control group,and non-disease area control group.We collected soil,food and blood,which were used to detect selenium content,and assay IgN antibody of CVB in plasma.The selenium content of blood was determined with hydride generation atomic fluorometry spectrometrie.The lgM antibody of CVB was measured with ELISA test Kit.Results Compared with those in non-disease areas,selenium content of soil,maize,wheat and bean(0.092 ±0.011,0.003±0.001,0.005±0.003,0.006±0.001)μg/L in disease area Welre significantly lower(t=17.007.8.551,15.842,12.109;all P<0.01).In disease area,the levels of blood selenium in disease area KD group(34.803.±13.302)μg/L was obviously decreased compared to disease area control group(41.235±13.571) μg/L (P<0.05).The rate of CVB infection among disease area KD group,control in disease area and control in non-disease area were 90.0%,68.3%and 45.8%.The odds ratio(OR) value of CVB infected exposure between disease area and non-disease areas was 3.957,and the 95% confidence interval(CI)Was 1.898～8.246.The OR value of CVB infected exposure between KD group and control group was 4.171,with the 95%CI of 1.298～13.404.Compared with CVB non-infection group,blood selenium of CVB infection group was,lower,but not significanfly(t=1.179, P>0.05).Conclusions Selenium deficiency and CVB infection still exist in KD area,Heilongjiang Province.
