CAJ | 학술논문

目的分析胰腺癌根治性切除术后DSA下应用健择区域辅助化疗预防转移复发的效果.方法哈医大附属第二医院1999年1月至2003年1月同一手术组行胰头癌和胰体尾癌根治性切除术97例,其中46例于手术后1个月DSA下经胃十二指肠动脉(GDA)、肠系膜上动脉(SMA)和(或)脾动脉(SA)灌注化学治疗药物健择作为试验组,此后根据情况每隔2个月重复一次,另外51例未做术后化疗者作为对照组.结果对术后辅助化疗者随访至2006年1月,1、3、5年生存率试验组为85.2%、52.9%和11.8%,对照组为65.4%、33.6%、5.3%;试验组1、3、5年累积复发转移率为28.9%、60.5%和88.3%,低于对照组的36.0%、78.3%和94.6%(P＜0.05);中位转移复发时间试验组为30.4个月,对照组为19.8个月.结论胰腺癌根治术后区域辅助化疗能有效降低胰腺癌的复发与转移率,提高胰腺癌病人生存时间.
목적 분석이선암근치성절제술후DSA하응용건택구역보조화료예방전이복발적효과.방법 합의대부속제이의원1999년1월지2003년1월동일수술조행이두암화이체미암근치성절제술97례,기중46례우수술후1개월DSA하경위십이지장동맥(GDA)、장계막상동맥(SMA)화(혹)비동맥(SA)관주화학치료약물건택작위시험조,차후근거정황매격2개월중복일차,령외51례미주술후화료자작위대조조.결과 대술후보조화료자수방지2006년1월,1、3、5년생존솔시험조위85.2%、52.9%화11.8%,대조조위65.4%、33.6%、5.3%;시험조1、3、5년루적복발전이솔위28.9%、60.5%화88.3%,저우대조조적36.0%、78.3%화94.6%(P＜0.05);중위전이복발시간시험조위30.4개월,대조조위19.8개월.결론 이선암근치술후구역보조화료능유효강저이선암적복발여전이솔,제고이선암병인생존시간.
Objective To evaluate the therapeutic effect of using regional adjuvant chemotherapy with the method of intra-arterial Gemzar infusion under the digital subtraction angiography(DSA)to prevent the metastasis and recurrence of the pancreatic carcinoma after radical resection.Methods The clinical data of 97 patients with pancreatic cancer treated in our hospital from 1999 to 2003 were retrospectively analyzed.All of them were treated with the radical resection of pancreatic cancer.Forty-six of them were infused with Gemzar through gastroduodenal artery(GDA),superior mesenteric artery(SMA)and/or splenic artery(SA)a month later after operation as experimental group.repeat it every 2 months according to the conditions of the patients The rest patients who did not received chemotherapy were employed to serve as the controls.Results The patients receiving regional adjuvant chemotherapy were followed up until Jan 2006,the 1-,3- and 5-year survival rate was 85.2%,52.9%,and 11.8%,respectively,in experimental group,65.4%,33.6% and 5.3%in control group.The cumulative metastatic and recurrent rates of experimental group in 1,3 and 5 years were 28.9%,60.5% and 88.3%,respectively.Which were significantly lower than those of control group (P＜0.05).The median time of metastasis and recurrence was 30.4 months in experimental group and 19.8 months in the control.Conclusion Regional adjuvant chemotherapy can decrease the metastatic and recurrent rates effectively after the radical resection of pancreatic carcinoma and improve the patients'survival.