中国医药
中國醫藥
중국의약
CHINA MEDICINE
2012年
10期
1211-1212
,共2页
李娟%丛阳%郭瑛%谭跃萍
李娟%叢暘%郭瑛%譚躍萍
리연%총양%곽영%담약평
冠状动脉疾病%内皮,血管%超声心动描记术
冠狀動脈疾病%內皮,血管%超聲心動描記術
관상동맥질병%내피,혈관%초성심동묘기술
Coronary artery disease%Endothelium,vascular%Echocardiography
目的 探讨经胸超声心动图技术结合干预试验测定冠心病患者冠状动脉内皮功能的方法.方法 冠状动脉造影(CAG)正常或管腔直径狭窄＜50％且无冠心病易患因素者为对照组(32例)；至少1支冠状动脉主支或其主要分支(对角支、钝缘支和后降支)狭窄 ≥50％即诊断为冠心病,纳入观察组(26例).用体表超声心动图显示右冠状动脉,在二维指导下M型分别测定基础、冷加压、复温及舌下含服硝酸甘油时右冠状动脉内径变化,并计算各组冷加压和含服硝酸甘油干预后内径增加率.结果 冷加压干预后,对照组的内径增加率明显大于观察组,组间比较差异有统计学意义[(24.3±1.4)％比(7.7±1.0)％,P＜0.01].硝酸甘油干预后,对照组内径增加率高于观察组,但组间比较差异无统计学意义[(24.5±1.5)％比(19.8±1.8)％,P＞0.05].结论 冠心病患者存在着内皮依赖性的舒张作用消失,本方法可区分出冠心病和非冠心病患者冠状动脉内皮依赖和非依赖性舒张状态,为体表超声心动图直接测定冠状动脉内皮功能提供参考.
目的 探討經胸超聲心動圖技術結閤榦預試驗測定冠心病患者冠狀動脈內皮功能的方法.方法 冠狀動脈造影(CAG)正常或管腔直徑狹窄＜50％且無冠心病易患因素者為對照組(32例)；至少1支冠狀動脈主支或其主要分支(對角支、鈍緣支和後降支)狹窄 ≥50％即診斷為冠心病,納入觀察組(26例).用體錶超聲心動圖顯示右冠狀動脈,在二維指導下M型分彆測定基礎、冷加壓、複溫及舌下含服硝痠甘油時右冠狀動脈內徑變化,併計算各組冷加壓和含服硝痠甘油榦預後內徑增加率.結果 冷加壓榦預後,對照組的內徑增加率明顯大于觀察組,組間比較差異有統計學意義[(24.3±1.4)％比(7.7±1.0)％,P＜0.01].硝痠甘油榦預後,對照組內徑增加率高于觀察組,但組間比較差異無統計學意義[(24.5±1.5)％比(19.8±1.8)％,P＞0.05].結論 冠心病患者存在著內皮依賴性的舒張作用消失,本方法可區分齣冠心病和非冠心病患者冠狀動脈內皮依賴和非依賴性舒張狀態,為體錶超聲心動圖直接測定冠狀動脈內皮功能提供參攷.
목적 탐토경흉초성심동도기술결합간예시험측정관심병환자관상동맥내피공능적방법.방법 관상동맥조영(CAG)정상혹관강직경협착＜50％차무관심병역환인소자위대조조(32례)；지소1지관상동맥주지혹기주요분지(대각지、둔연지화후강지)협착 ≥50％즉진단위관심병,납입관찰조(26례).용체표초성심동도현시우관상동맥,재이유지도하M형분별측정기출、랭가압、복온급설하함복초산감유시우관상동맥내경변화,병계산각조랭가압화함복초산감유간예후내경증가솔.결과 랭가압간예후,대조조적내경증가솔명현대우관찰조,조간비교차이유통계학의의[(24.3±1.4)％비(7.7±1.0)％,P＜0.01].초산감유간예후,대조조내경증가솔고우관찰조,단조간비교차이무통계학의의[(24.5±1.5)％비(19.8±1.8)％,P＞0.05].결론 관심병환자존재착내피의뢰성적서장작용소실,본방법가구분출관심병화비관심병환자관상동맥내피의뢰화비의뢰성서장상태,위체표초성심동도직접측정관상동맥내피공능제공삼고.
Objective To explore a way to determine endothelium function of coronary heart disease (CHD)by echocardiography combined with intervention experiment.Methods The control group consisted of 32 subjects with no risk factors for coronary artery disease; The observation group consisted of 26 subjects diagnosed of CHD by coronary arteriongraphy with coronary arteries stenosis more than 50％.All subjects were examined by echocardiography to record variation of the right coronary artery(RCA)diameter which responses to resting condition, cold pressor test and sublingual nitroglycerin.The changes of right coronary artery diameter were calculated.Results After cold pressor test,the increase rate of diameter in control group was more significant than that in observation group[(24.3± 1.4)％ vs(7.7 ± 1.0)％,P ＜ 0.01]; there was no significant difference about the increase rate of diameter between control group and observation group after nitroglycerin.Conclusions Patients with CHD can have the coronary endothelium-dependent dilatation,which can distinguish patients with CHD and patients without CHD in coronary endothelium function.This method can be conveniently used to evaluate endothelium function by echocardiogram.
