CAJ | 학술논문

黄褐斑是一种面部获得性色素增加性皮肤病,发病机制尚不清,概述黄褐斑的表皮屏障及黑素屏障的变化,以及真皮血管的变化.在此基础上推测黄褐斑的可能发病机制为紫外线、化妆品、避孕药等不良刺激导致表皮屏障功能障碍,代偿性引起黑素细胞功能活跃,黑素屏障增强,形成临床上表现为色素沉着为主的皮肤病.进一步导致真皮毛细血管扩张,血管内皮生长因子表达增加,促进色素沉着发生.
황갈반시일충면부획득성색소증가성피부병,발병궤제상불청,개술황갈반적표피병장급흑소병장적변화,이급진피혈관적변화.재차기출상추측황갈반적가능발병궤제위자외선、화장품、피잉약등불량자격도치표피병장공능장애,대상성인기흑소세포공능활약,흑소병장증강,형성림상상표현위색소침착위주적피부병.진일보도치진피모세혈관확장,혈관내피생장인자표체증가,촉진색소침착발생.
Melasma is an acquired skin disease characterized by facial hyperpigmentation of unclear pathogenesis.This paper describes the changes of epidermal barrier,melanin barrier and dermal blood vessels in melasma.On this basis,the pathogenesis of melasma is speculated to be associated with ultraviolet,cosmetics,contraceptives and other adverse stimuli,which cause epidermal barrier dysfunction,lead to a compensatory increase in melanocyte activity and melanin barrier followed by the occurrence of diseases characterized by skin pigmentation.Moreover,dermal telangiectasis is induced and vascular endothelial growth factor expression is enhanced,which accelerate skin pigmentation accordingly.