CAJ | 학술논문

目的研究富含脯氨酸的酪氨酸蛋白激酶2(proline-rich tyrosine kinase-2,Pyk2)在人原发性大肠癌组织中的表达及其对大肠癌患者预后判断的意义.方法应用免疫组织化学方法检测108例原发性大肠癌组织中Pyk2的表达水平,分析Pyk2表达差异与预后的相关性及与临床相关因素的关系.结果在原发性大肠癌组织中Pyk2低表达率为56.5%(61/108);Pyk2表达水平与肿瘤组织学分级显著相关(P＜0.05),与TNM分期显著相关(P＜0.05),而与患者年龄、肿瘤大小等无关(P＞0.05);Pyk2高表达组患者根治术后五年生存率(66.0%)明显高于低表达组(31.4%);多因素分析显示,Pyk2表达水平、肿瘤组织学分级以及TNM分期是影响大肠癌预后的因素.结论 Pyk2表达水平是影响原发性大肠癌预后的因素之一,可与其他因素联合作为判断大肠癌预后的参考指标.
목적 연구부함포안산적락안산단백격매2(proline-rich tyrosine kinase-2,Pyk2)재인원발성대장암조직중적표체급기대대장암환자예후판단적의의.방법 응용면역조직화학방법검측108례원발성대장암조직중Pyk2적표체수평,분석Pyk2표체차이여예후적상관성급여림상상관인소적관계.결과 재원발성대장암조직중Pyk2저표체솔위56.5%(61/108);Pyk2표체수평여종류조직학분급현저상관(P＜0.05),여TNM분기현저상관(P＜0.05),이여환자년령、종류대소등무관(P＞0.05);Pyk2고표체조환자근치술후오년생존솔(66.0%)명현고우저표체조(31.4%);다인소분석현시,Pyk2표체수평、종류조직학분급이급TNM분기시영향대장암예후적인소.결론 Pyk2표체수평시영향원발성대장암예후적인소지일,가여기타인소연합작위판단대장암예후적삼고지표.
Objective To investigate the expression of proline-rich tyrosine kinase-2(Pyk2)in human primary colorectal carcinoma(CRC)and it's prognostic significance.Methods The expression of Pyk2 was retrospectively examined with immunohistochemistry(IHC)in 108 tissues of primary CRC.The correlation of Pyk2 expression to prognosis and relevant clinical factors were analyzed.Results The rate of Pyk2 low-expression in CRC was 56.5%(61/108).The expression of Pyk2 correlated significantly to the histological grade(P＜0.05)and the TNM stage(P＜0.05),while no correlation between Pyk2 expression and age,tumor size(P＞0.05).Patients with Pyk2 over-expression had significantly higher 5-year survival rate(66.0%)than those with Pyk2 low-expression(31.4%).Pyk2 expression,together with carcinoma histologic grade and TNM stage were prognostic factors to CRC on the multivariate analysis.Conclusions Pyk2 expression canbe a prognostic factor to the CRC patients together with other predictors.