中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
3期
69-71
,共3页
慢性阻塞性肺疾病%肿瘤坏死因子α%白细胞介素-8%白细胞介素-6%临床分期%气流受限
慢性阻塞性肺疾病%腫瘤壞死因子α%白細胞介素-8%白細胞介素-6%臨床分期%氣流受限
만성조새성폐질병%종류배사인자α%백세포개소-8%백세포개소-6%림상분기%기류수한
Chronic obstructive pulmonary disease%TNF-α%IL-8%IL-6%Clinical stages%Airflow limitation
目的 探讨慢性阻塞性肺疾病(COPD)患者血清中肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)和白细胞介素-6(IL-6)的浓度变化及其与临床分期、气流受限之间的关系.方法 选择120例COPD患者(急性加重期60例,稳定期60例)作为研究组和30例健康体检者作为对照组,分别抽取空腹外周静脉血并分离血清,采用酶联免疫法( ELISA)检测血清中TNF-α、IL-8、IL-6的水平,并根据临床分期、气流受限程度分组比较.结果 COPD急性加重期和缓解期患者血清TNF-α、IL-8、IL-6水平明显高于健康对照组(P＜0.05),COPD急性加重期TNF-α、IL-8、IL-6水平明显高于缓解期患者(P＜0.05).COPD患者随着通气障碍程度(轻度、中度、重度)的加重血清TNF-α、IL-8、IL-6水平逐渐升高,组间比较差异有统计学意义(P＜0.05).结论 TNF-α、IL-8、IL-6共同参与了COPD的发病机制,在气道炎性反应中起着重要作用,并与COPD的临床分期、气流受限程度密切相关.
目的 探討慢性阻塞性肺疾病(COPD)患者血清中腫瘤壞死因子-α(TNF-α)、白細胞介素-8(IL-8)和白細胞介素-6(IL-6)的濃度變化及其與臨床分期、氣流受限之間的關繫.方法 選擇120例COPD患者(急性加重期60例,穩定期60例)作為研究組和30例健康體檢者作為對照組,分彆抽取空腹外週靜脈血併分離血清,採用酶聯免疫法( ELISA)檢測血清中TNF-α、IL-8、IL-6的水平,併根據臨床分期、氣流受限程度分組比較.結果 COPD急性加重期和緩解期患者血清TNF-α、IL-8、IL-6水平明顯高于健康對照組(P＜0.05),COPD急性加重期TNF-α、IL-8、IL-6水平明顯高于緩解期患者(P＜0.05).COPD患者隨著通氣障礙程度(輕度、中度、重度)的加重血清TNF-α、IL-8、IL-6水平逐漸升高,組間比較差異有統計學意義(P＜0.05).結論 TNF-α、IL-8、IL-6共同參與瞭COPD的髮病機製,在氣道炎性反應中起著重要作用,併與COPD的臨床分期、氣流受限程度密切相關.
목적 탐토만성조새성폐질병(COPD)환자혈청중종류배사인자-α(TNF-α)、백세포개소-8(IL-8)화백세포개소-6(IL-6)적농도변화급기여림상분기、기류수한지간적관계.방법 선택120례COPD환자(급성가중기60례,은정기60례)작위연구조화30례건강체검자작위대조조,분별추취공복외주정맥혈병분리혈청,채용매련면역법( ELISA)검측혈청중TNF-α、IL-8、IL-6적수평,병근거림상분기、기류수한정도분조비교.결과 COPD급성가중기화완해기환자혈청TNF-α、IL-8、IL-6수평명현고우건강대조조(P＜0.05),COPD급성가중기TNF-α、IL-8、IL-6수평명현고우완해기환자(P＜0.05).COPD환자수착통기장애정도(경도、중도、중도)적가중혈청TNF-α、IL-8、IL-6수평축점승고,조간비교차이유통계학의의(P＜0.05).결론 TNF-α、IL-8、IL-6공동삼여료COPD적발병궤제,재기도염성반응중기착중요작용,병여COPD적림상분기、기류수한정도밀절상관.
Objective To investigate the serum levels TNF-a,IL- 8 and lL-6 levels and their relationships to clinical stages and airflow limitation in patients with chronic obstructive pulmonary disease ( COPD).Methods The serum was sampled and prepared from 120 cases of COPD( exacerbation group 60 cases,remission group 60 cases) patients and 30 healthy persons.Serum level of TNF-α,IL-8 and IL-6 were detected by ELISA,they were statistically analyzed according to clinical stages,airflow obstruction limitation.Results Levels of TNF-α,IL-8 and IL-6 in the cases of the COPD stable time and the period of AECOPD were higher than the healthy cases (P ＜ 0.05).Levels of TNF-α,IL-8 and IL-6 in the period of AECOPD were higher than in the cases of the COPD stable time (P ＜ 0.05).Levels of TNF-α,IL- 8 and IL-6 0f ventilated function obstacle groups of medium scan and heavy scan were higher than light scan group (P ＜ 0.05).Conclusions TNF-α,lL-8 and IL-6 are involved in airway inflammation,TNF-α,IL-8 and IL-6 not only take part in the acute inflammation in COPD,but also are closely correlated with clinical stages and airflow limitation.
