中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2012年
1期
18-20
,共3页
米非司酮%人工流产%残留
米非司酮%人工流產%殘留
미비사동%인공유산%잔류
Mifepristone%Induced abortion%Remnants
目的 探讨不同用药方案的米非司酮治疗人工流产术后残留的有效性及安全性.方法 对象为自2009年10月至2011年2月复旦大学附属妇产科医院计划生育门诊就诊的流产后妇女,通过B超及血β-人绒毛膜促性腺激素(HCG)明确诊断为残留的对象,共101例,随机分为4组.按每日服用米非司酮计量不同分3组(3组计量分别是200 mg 7 d,100 mg 14 d,50 mg 28 d),另设对照组(服头孢呋辛酯),通过临床观察,B超及血β-HCG监测,比较4组的治疗效果及安全性.结果 米非司酮治疗组有效率61.60％(45/73),对照组治疗有效率21.40％(6/28),两者比较差异有统计学意义(P＜0.01).用药2周后血β-HCG和B超结果,治疗组明显好于对照组,差异有统计学意义(P＜0.01),其中大剂量组治疗效果最为明显；用药4周后米非司酮治疗3组间血β-HCG差异无统计学意义(P＞0.05),3组间宫内残留组织物缩小差异有统计学意义(P＜0.05),其中短时间大剂量组缩小最为明显.4组的阴道流血停止时间、转经时间差异有统计学意义(P＜0.05).治疗3组在治愈时间上差异无统计学意义(P＞0.05).治疗3组不良反应的发生率差异无统计学意义(P＞0.05).结论运用米非司酮保守治疗人工流产术后残留有效,而且短时间大剂量的给药方式更有效.
目的 探討不同用藥方案的米非司酮治療人工流產術後殘留的有效性及安全性.方法 對象為自2009年10月至2011年2月複旦大學附屬婦產科醫院計劃生育門診就診的流產後婦女,通過B超及血β-人絨毛膜促性腺激素(HCG)明確診斷為殘留的對象,共101例,隨機分為4組.按每日服用米非司酮計量不同分3組(3組計量分彆是200 mg 7 d,100 mg 14 d,50 mg 28 d),另設對照組(服頭孢呋辛酯),通過臨床觀察,B超及血β-HCG鑑測,比較4組的治療效果及安全性.結果 米非司酮治療組有效率61.60％(45/73),對照組治療有效率21.40％(6/28),兩者比較差異有統計學意義(P＜0.01).用藥2週後血β-HCG和B超結果,治療組明顯好于對照組,差異有統計學意義(P＜0.01),其中大劑量組治療效果最為明顯；用藥4週後米非司酮治療3組間血β-HCG差異無統計學意義(P＞0.05),3組間宮內殘留組織物縮小差異有統計學意義(P＜0.05),其中短時間大劑量組縮小最為明顯.4組的陰道流血停止時間、轉經時間差異有統計學意義(P＜0.05).治療3組在治愈時間上差異無統計學意義(P＞0.05).治療3組不良反應的髮生率差異無統計學意義(P＞0.05).結論運用米非司酮保守治療人工流產術後殘留有效,而且短時間大劑量的給藥方式更有效.
목적 탐토불동용약방안적미비사동치료인공유산술후잔류적유효성급안전성.방법 대상위자2009년10월지2011년2월복단대학부속부산과의원계화생육문진취진적유산후부녀,통과B초급혈β-인융모막촉성선격소(HCG)명학진단위잔류적대상,공101례,수궤분위4조.안매일복용미비사동계량불동분3조(3조계량분별시200 mg 7 d,100 mg 14 d,50 mg 28 d),령설대조조(복두포부신지),통과림상관찰,B초급혈β-HCG감측,비교4조적치료효과급안전성.결과 미비사동치료조유효솔61.60％(45/73),대조조치료유효솔21.40％(6/28),량자비교차이유통계학의의(P＜0.01).용약2주후혈β-HCG화B초결과,치료조명현호우대조조,차이유통계학의의(P＜0.01),기중대제량조치료효과최위명현；용약4주후미비사동치료3조간혈β-HCG차이무통계학의의(P＞0.05),3조간궁내잔류조직물축소차이유통계학의의(P＜0.05),기중단시간대제량조축소최위명현.4조적음도류혈정지시간、전경시간차이유통계학의의(P＜0.05).치료3조재치유시간상차이무통계학의의(P＞0.05).치료3조불량반응적발생솔차이무통계학의의(P＞0.05).결론운용미비사동보수치료인공유산술후잔류유효,이차단시간대제량적급약방식경유효.
Objective To evaluate the efficacy and safety of treating abortive remnants of induced abortion with different doses of mifepristone.Methods A total of 101 women undergoing post-abortion treatment at our family planning clinic from October 2009 to February 2011 were recruited and divided randomly into 4 groups.They were diagnosed as abortive remnants by ultrasound and blood level of β-HCG (human chorionic gonadotrophin).Three test groups received different doses of mifepristone and one group as control. The efficacy and safety of four groups were evaluated by clinical observations,ultrasonic examinations and blood level of β-HCG.Results The effective rates of mifepristone test and control groups were 61.60％ and 21.40％ respectively.And there were statistical significances between two groups ( P ＜ 0.01 ).After a 2-week treatment,the changes of blood level of β-HCG and reduction of residual size tested by ultrasound were better than those of the control group.And there were significant statistical differences (P ＜0.01 ). The group with high dose in short term achieved the best outcomes. After four weeks of treatment,blood level of β-HCG of test groups had no statistical significance ( P ＞ 0.05 ).There was statistical significance in pairwise comparison on reduction of residual size tested by ultrasound among test groups ( P ＜ 0.05 ). The high-dose group with achieved the largest short-term reduction. Statistical significances existed in the hemostatic time of vaginal hemorrhage and menstrual recovery between three test groups and the control group ( P ＜ 0.05 ). No statistical significance was found in healing time and the occurrence of adverse events among these 3 test groups ( both P ＞ 0.05 ).Conclusion Mifepristone is effective in the treatment of induced incomplete abortion.And a short-term large dose offers a better efficacy.
