CAJ | 학술논문

目的探讨液基薄层细胞学制片技术(LCT)在非妇科细胞学诊断中的应用价值及临床意义.方法 485例非妇科细胞学标本同时分别采用传统涂片法及液基薄层细胞学方法进行检查、阅片、诊断,将两组结果比较并进行统计学处理.结果 LCT制片与传统涂片相比,前者细胞数量多且集中、薄层均匀、染色背景干净、核染色质着色鲜明、胞浆清楚、单个细胞界限分明,易于鉴别良恶性病变及肿瘤类型.传统涂片细胞核染色质着色均一模糊、缺乏立体感,染色背景欠清晰.普通涂片确诊癌50例(10.3％),可疑癌121例(24.9％),阴性314例(64.7％)；LCT制片确诊癌117例(24.1％),可疑癌113例(23.3％),阴性255例(52.6％).结论 LCT液基薄层细胞学制片技术在非妇科细胞学标本制片质量及诊断准确性明显高于传统涂片方法,两种制片方法的恶性细胞确诊率比较差异有统计学意义(P＜0.01).
목적 탐토액기박층세포학제편기술(LCT)재비부과세포학진단중적응용개치급림상의의.방법 485례비부과세포학표본동시분별채용전통도편법급액기박층세포학방법진행검사、열편、진단,장량조결과비교병진행통계학처리.결과 LCT제편여전통도편상비,전자세포수량다차집중、박층균균、염색배경간정、핵염색질착색선명、포장청초、단개세포계한분명,역우감별량악성병변급종류류형.전통도편세포핵염색질착색균일모호、결핍입체감,염색배경흠청석.보통도편학진암50례(10.3％),가의암121례(24.9％),음성314례(64.7％)；LCT제편학진암117례(24.1％),가의암113례(23.3％),음성255례(52.6％).결론 LCT액기박층세포학제편기술재비부과세포학표본제편질량급진단준학성명현고우전통도편방법,량충제편방법적악성세포학진솔비교차이유통계학의의(P＜0.01).
Objective To investigate the applied value and clinical significance of gravitational settling style LCT in non - gynecology cytodiagnosis.Methods Four hundred and eighty - five cases of non - gynecology cytological sample were detected by routine smear test and LCT respectively,and then the accessing and diagnosis were made.At last statistical analysis was carried out to find the differences between the two methods.Results Comparing LCT with routine smear test,the difference had been found as follows.The former had higher quantity and more concentrated cell,more uniform papanicolaou smears,cleaner dyeing background,brighter color nuclear chromatin,more distinct endochylema,clearer single cell boundary,identifying benign lesion from malignant one and differentiating the category of tumor easierly.However,the nuclear chromatin of the latter was more monotonus,vague and less stereo,dyeing background was less cleaner.In these cases,the cases (percentage) of cancer,doubtful cancer and the negative were 50 ( 10.3 ％ ),121 (24.9％) and 314 (64.7％),respectively,which were diagnosed by routine smear test.Correspondingly,the result of diagnosis made by LCT were 117 cases (24.1％ ),113 cases (23.3％),255 cases(52.6％ ),respectively.Conclusions LCT was better than routine smear test in the quality of slice making and the accuracy of diagnosis on non - gynecology cytological sample,.The difference of the two test in the rate of final diagnosis of malignant cell was significant ( P ＜ 0.01 ).