中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2012年
4期
282-285
,共4页
周艳茹%刘秀荣%吴寿岭%王丽晔%闫秀纵%刘业强%曹正新%史丽萍
週豔茹%劉秀榮%吳壽嶺%王麗曄%閆秀縱%劉業彊%曹正新%史麗萍
주염여%류수영%오수령%왕려엽%염수종%류업강%조정신%사려평
空腹血糖%糖尿病%脑梗死
空腹血糖%糖尿病%腦梗死
공복혈당%당뇨병%뇌경사
Fasting plasma glucose%Diabetes mellitus%Cerebral infarction
目的 探讨糖尿病人群空腹血糖水平与新发脑梗死事件的相关性.方法 采用前瞻性队列研究方法,以空腹血糖≥7.0 mmol/L或＜7.0 mmol/L但已确诊为糖尿病、正在使用降糖药物的8 306例糖尿人群作为观察队列,随访(48.01 ±3.14)个月,随访期间每半年收集一次新发脑梗死事件情况.分析糖尿病人群空腹血糖水平与新发脑梗死事件的相关性.结果 (1)随访结束时,随着基线空腹血糖水平的增高,研究对象的总胆固醇、甘油三酯的水平逐渐增高[总胆固醇:(4.93±1.15,510±1.20,5.15± 1.28,5.33±1.35) mmol/L,甘油三酯:(1.70±1.26,1.83± 1.29,2.18±1.76,2.41±2.08) mmol/L,P＜0.05];低密度脂蛋白胆固醇、收缩压、舒张压、体重指数的水平也增高(P＜0.05).(2) 7.0 mmol/L≤空腹血糖＜9.0mmol/L组累积发生脑梗死事件率最低(2.1％,P＜0.01).校正年龄、性别、收缩压、舒张压、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、体重指数、吸烟、糖尿病病程及降糖治疗因素,Cox比例风险回归分析表明,相对于7.0 mmol/L≤空腹血糖＜9.0 mmoL/L组,6.1 mmol/L≤空腹血糖＜7.0mmol/L组和空腹血糖≥9 mmol/L两组发生脑梗死事件的相对危险(RR)各分别增加1.85倍(95％CI 1.09～3.15,P＜0.05)、1.54倍(95％CI 1.16～2.05,P＜0.01).结论 糖尿病人群空腹血糖控制在7.0 ～9.0 mmol/L水平者似新发生脑梗死事件率最低.
目的 探討糖尿病人群空腹血糖水平與新髮腦梗死事件的相關性.方法 採用前瞻性隊列研究方法,以空腹血糖≥7.0 mmol/L或＜7.0 mmol/L但已確診為糖尿病、正在使用降糖藥物的8 306例糖尿人群作為觀察隊列,隨訪(48.01 ±3.14)箇月,隨訪期間每半年收集一次新髮腦梗死事件情況.分析糖尿病人群空腹血糖水平與新髮腦梗死事件的相關性.結果 (1)隨訪結束時,隨著基線空腹血糖水平的增高,研究對象的總膽固醇、甘油三酯的水平逐漸增高[總膽固醇:(4.93±1.15,510±1.20,5.15± 1.28,5.33±1.35) mmol/L,甘油三酯:(1.70±1.26,1.83± 1.29,2.18±1.76,2.41±2.08) mmol/L,P＜0.05];低密度脂蛋白膽固醇、收縮壓、舒張壓、體重指數的水平也增高(P＜0.05).(2) 7.0 mmol/L≤空腹血糖＜9.0mmol/L組纍積髮生腦梗死事件率最低(2.1％,P＜0.01).校正年齡、性彆、收縮壓、舒張壓、總膽固醇、甘油三酯、低密度脂蛋白膽固醇、高密度脂蛋白膽固醇、體重指數、吸煙、糖尿病病程及降糖治療因素,Cox比例風險迴歸分析錶明,相對于7.0 mmol/L≤空腹血糖＜9.0 mmoL/L組,6.1 mmol/L≤空腹血糖＜7.0mmol/L組和空腹血糖≥9 mmol/L兩組髮生腦梗死事件的相對危險(RR)各分彆增加1.85倍(95％CI 1.09～3.15,P＜0.05)、1.54倍(95％CI 1.16～2.05,P＜0.01).結論 糖尿病人群空腹血糖控製在7.0 ～9.0 mmol/L水平者似新髮生腦梗死事件率最低.
목적 탐토당뇨병인군공복혈당수평여신발뇌경사사건적상관성.방법 채용전첨성대렬연구방법,이공복혈당≥7.0 mmol/L혹＜7.0 mmol/L단이학진위당뇨병、정재사용강당약물적8 306례당뇨인군작위관찰대렬,수방(48.01 ±3.14)개월,수방기간매반년수집일차신발뇌경사사건정황.분석당뇨병인군공복혈당수평여신발뇌경사사건적상관성.결과 (1)수방결속시,수착기선공복혈당수평적증고,연구대상적총담고순、감유삼지적수평축점증고[총담고순:(4.93±1.15,510±1.20,5.15± 1.28,5.33±1.35) mmol/L,감유삼지:(1.70±1.26,1.83± 1.29,2.18±1.76,2.41±2.08) mmol/L,P＜0.05];저밀도지단백담고순、수축압、서장압、체중지수적수평야증고(P＜0.05).(2) 7.0 mmol/L≤공복혈당＜9.0mmol/L조루적발생뇌경사사건솔최저(2.1％,P＜0.01).교정년령、성별、수축압、서장압、총담고순、감유삼지、저밀도지단백담고순、고밀도지단백담고순、체중지수、흡연、당뇨병병정급강당치료인소,Cox비례풍험회귀분석표명,상대우7.0 mmol/L≤공복혈당＜9.0 mmoL/L조,6.1 mmol/L≤공복혈당＜7.0mmol/L조화공복혈당≥9 mmol/L량조발생뇌경사사건적상대위험(RR)각분별증가1.85배(95％CI 1.09～3.15,P＜0.05)、1.54배(95％CI 1.16～2.05,P＜0.01).결론 당뇨병인군공복혈당공제재7.0 ～9.0 mmol/L수평자사신발생뇌경사사건솔최저.
Objective To study the relationship between fasting plasma glucose (FPG) level and the first cerebral infarction event in the population with diabetes.Methods This was a prospective cohort stndy.8 306 diabetic subjects who determined FPG ≥ 7.0 mmol/L or treated with insulin or hypoglycemic drugs and FPG ＜7.0 mmool/L as the observation population and were followed-up for (48.01 ± 3.14) months.During the course,cerebral infarction events were determined every 6 months.Results ( 1 ) By the end of following-up,with the increasing levels of the baseline FPG,the total cholesterol (TC),triglyceride (TG) levels were gradually increased in the diabetic population,the differences were significant [ TC:( 4.93 ± 1.15,5.10 ± 1.20,5.15 ± 1.28,5.33 ± 1.35 ) mmol/L,TG:( 1.70 ± 1.26,1.83 ± 1.29,2.18 ± 1.76,2.41 ± 2.08 ) mmol/L,P＜0.05 ] ; the plasma low density lipoprotein-cholesterol (LDL-C),systolic blood pressure ( SBP),diastolic blood pressure ( DBP),and body mass index (BMI) levels were also increased significantly ( P＜0.05 ).(2) The ineidence of cerebral infarction event in the group of patients with 7.0 mnol/L ≤ FPG ＜ 9.0 mmol/L was the lowest,the differences were significant ( 2.1％,P ＜0.01 ).Compared with the group of 7.0 mmol/L≤ FPG＜9.0 mmol/L,after adjusting for age,sex,BMI,SBP,DBP,TC,TG,low density lipoprotein-cholesterol,high density lipoprotein-cholesterol,smoking,diabetic duration and treatment,the relative risk for cerebral infarction events were 1.85 (95％ CI 1.09-3.15,P＜0.05) and 1.54 (95％CI 1.16-2.05,P ＜ 0.01 ) for those groups with 6.1 mmol/L ≤ FPG ＜ 7.0 mmol/L and FPG ≥ 9.0 mmol/L respectively.Conclusion The risk of new in cidence of cerebral infarction events seems to be the lowest in the group of diabetic patients whose FPGs are wihin 7.0-9.0 mmol/L range.
