CAJ | 학술논문

到目前为止,食物过敏治疗尚没有确切的有效治疗方法,主要采用回避过敏原和针对严重过敏反应急诊处理等方法,口服免疫治疗(oral immunotherapy,OIT)作为一种新的食物过敏治疗方法,它能诱导IgE介导的儿童食物过敏的脱敏,但仍不了解诱导耐受的状况能否持续.虽然OIT治疗过程中发生严重过敏反应并不多见,但不良反应是共同存在的.今后需在严格设计的多中心随机、双盲、对照研究基础上,进一步了解OIT治疗后过敏原耐受状况能否维持,并明确耐受的特异性实验室指标.
도목전위지,식물과민치료상몰유학절적유효치료방법,주요채용회피과민원화침대엄중과민반응급진처리등방법,구복면역치료(oral immunotherapy,OIT)작위일충신적식물과민치료방법,타능유도IgE개도적인동식물과민적탈민,단잉불료해유도내수적상황능부지속.수연OIT치료과정중발생엄중과민반응병불다견,단불량반응시공동존재적.금후수재엄격설계적다중심수궤、쌍맹、대조연구기출상,진일보료해OIT치료후과민원내수상황능부유지,병명학내수적특이성실험실지표.
At present there is no definitive therapy for food allergy and the mainstays of treatment are allergen avoidance and ready access to emergency medications. Significant progress toward an novel oral immunotherapy (OIT)for food allergy has been made. These preliminary data on OIT are encouraging, OIT can be effective in desensitizing at least a subset of children with IgE-mediated food allergy, however, it remains uncertain whether OIT can induce long-term tolerance. During OIT, allergic reactions are common, although severe reactions are less common. Additional studies are needed to realize whether tolerance would be maintained, and to determine the specific laboratory indicators in rigorous multicenter randomized and placebo-controlled trials.