CAJ | 학술논문

目的观察肾移植术后早期不同剂量霉酚酸酯(MMF)与环孢素A(CsA)和泼尼松(Pred)联用预防急性排斥反应的效果及安全性.方法将64例肾移植患者分为3组,分别给予MMF 2.0g/d(A组)、1.5g/d(B组)及Aza 50～100mg/d(C组),每组均联用CsA及Pred(剂量相同).观察肾移植术后6个月内急性排斥反应的发生率、移植肾功能及药物的副作用.结果 A、B、C组急性排斥反应的发生率分别为11.1%、0及27.5%;A、B组消化道的副作用多见,尤以A组为高,其它副作用3个组的差异无显著性;移植肾功能延迟恢复的发生率,A、B两组明显高于C组.结论不同诱导剂量的MMF与CsA和Pred短期联用,可有效预防术后早期急性排斥反应的发生;MMF除胃肠道的副作用较多外,其它副作用未见增多.
목적 관찰신이식술후조기불동제량매분산지(MMF)여배포소A(CsA)화발니송(Pred)련용예방급성배척반응적효과급안전성.방법 장64례신이식환자분위3조,분별급여MMF 2.0g/d(A조)、1.5g/d(B조)급Aza 50～100mg/d(C조),매조균련용CsA급Pred(제량상동).관찰신이식술후6개월내급성배척반응적발생솔、이식신공능급약물적부작용.결과 A、B、C조급성배척반응적발생솔분별위11.1%、0급27.5%;A、B조소화도적부작용다견,우이A조위고,기타부작용3개조적차이무현저성;이식신공능연지회복적발생솔,A、B량조명현고우C조.결론 불동유도제량적MMF여CsA화Pred단기련용,가유효예방술후조기급성배척반응적발생;MMF제위장도적부작용교다외,기타부작용미견증다.
Objectives To investigate the efficiency and safety of combined use of different doses of Cellcept(MMF)with CsA and Pred at the early stage after renal transplantation for preventing and treating the acute renal allograft rejection.Methods Sixty-four cadaveric renal transplant recipients were randomly divided into 3 groups,receiving MMF 2.0 g/d,CsA and Pred(group A),MMF 1.5 g/d,CsA and Pred(group B)and Aza 50 to 100 mg/d,CsA and Pred(group C)respectively.The incidence of the acute renal allograft rejection,the function of the renal graft and the different adverse effects in the recipients at the first 6 months after renal transplantation were observed.Results The incidence of the acute rejection was 11.11%,0,27.5%in the groups A,B and C respectively.The frequency of diarrhea was the highest in the group A,and other side events were similar among the three groups.Conclusions Combined use of different doses of MMF with CsA and Pred could effectively prevent the occurrence of acute rejection at the early stage after transplantation.Except for the side events of gastrointestine,other MMF-induced side effects was not increased.