CAJ | 학술논문

目的探讨细胞因子在抑郁症发病中的作用。方法用酶联免疫吸附法检测22例抑郁症患者（抑郁症组）和20名正常人（对照组）的血清白细胞介素（IL）1-β、IL-2、IL-6、肿瘤坏死因子-α（TNF-α）和γ-干扰素（IFN-γ）水平，均以nmol/L计。结果抑郁症组血清IL-2水平为0.46±0.52，明显高于对照组的0.15±0.19（t=2.517，P<0.05）。抑郁症组的IL-1β、IL-6、TNF-α和IFN-γ水平分别为0.32±0.57，0.14±0.37，0.03±0.05和0.05±0.13，与对照组（分别为0.23±0.25, 0.08±0.23，0.05±0.09和0.01±0.04）比较，差异无显著性（t分别为0.645，0.589，1.099和1.110，P>0.05）。结论抑郁症患者的血清IL-2水平升高，提示IL-2可能在抑郁症的发病中起一定作用。
목적탐토세포인자재억욱증발병중적작용。방법용매련면역흡부법검측22례억욱증환자（억욱증조）화20명정상인（대조조）적혈청백세포개소（IL）1-β、IL-2、IL-6、종류배사인자-α（TNF-α）화γ-간우소（IFN-γ）수평，균이nmol/L계。결과억욱증조혈청IL-2수평위0.46±0.52，명현고우대조조적0.15±0.19（t=2.517，P<0.05）。억욱증조적IL-1β、IL-6、TNF-α화IFN-γ수평분별위0.32±0.57，0.14±0.37，0.03±0.05화0.05±0.13，여대조조（분별위0.23±0.25, 0.08±0.23，0.05±0.09화0.01±0.04）비교，차이무현저성（t분별위0.645，0.589，1.099화1.110，P>0.05）。결론억욱증환자적혈청IL-2수평승고，제시IL-2가능재억욱증적발병중기일정작용。
Objective　To investigate the association between cytokines and depression. Method　Serum levels of interleukin-1β(IL-1β), interleukin-2 (IL-2), interleukin-6 (IL-6),tumor necrosis factor-α(TNF-α) and γ-interferon (IFN-γ) were measured in 22 depressive patients and 20 normal control by ELISA. Results　The serum level of IL-2 in depression group (0.46 nmol/L±0.52 nmol/L)was significantly higher than that in control group (0.15 nmol/L±0.19 nmol/L， t=2.517, P<0.05). There was not significantly difference in serum levels of IL-1β、IL-6、TNF-α and IFN-γ between depression group and control group(t=0.645, 0.589, 1.099 and 1.110, respectively, P>0.05). Conclusions　It is suggested that IL-2 plays a role in pathogenesis of depression.