CAJ | 학술논문

目的探讨单纯口服降糖药(OHA)、单纯胰岛素强化治疗(Ins)对短病程、未用过降糖药的2型糖尿病(T2DM)患者减轻胰岛素抵抗、改善胰岛功能的效应差异.方法 60例病程≤1年、未用过降糖药的T2DM患者随机分为2组,即OHA组、Ins组.每组有效病例30人,进行强化降糖治疗,以末梢空腹血糖≤6.5mmol/L和餐后2 h血糖≤8.0mmol/L为血糖控制目标,使血糖在5～10 d达标,并维持达标4周.比较2组治疗前后的静脉葡萄糖耐量试验(IVGTT)胰岛素第一时相分泌、胰岛素抵抗指数(Homa A)和胰岛素分泌指数(Homa B)的变化.结果 2组治疗后IVGTT曲线下面积和Homa B均明显升高,Homa A明显下降.2组间治疗前后变化的差异不显著.结论 2种强化降糖治疗方案均可以使短病程、未用过降糖药的T2DM患者胰岛素抵抗以及胰岛β细胞功能得到同样程度的改善.
목적 탐토단순구복강당약(OHA)、단순이도소강화치료(Ins)대단병정、미용과강당약적2형당뇨병(T2DM)환자감경이도소저항、개선이도공능적효응차이.방법 60례병정≤1년、미용과강당약적T2DM환자수궤분위2조,즉OHA조、Ins조.매조유효병례30인,진행강화강당치료,이말소공복혈당≤6.5mmol/L화찬후2 h혈당≤8.0mmol/L위혈당공제목표,사혈당재5～10 d체표,병유지체표4주.비교2조치료전후적정맥포도당내량시험(IVGTT)이도소제일시상분비、이도소저항지수(Homa A)화이도소분비지수(Homa B)적변화.결과 2조치료후IVGTT곡선하면적화Homa B균명현승고,Homa A명현하강.2조간치료전후변화적차이불현저.결론 2충강화강당치료방안균가이사단병정、미용과강당약적T2DM환자이도소저항이급이도β세포공능득도동양정도적개선.
Objective To investigate the different effect of oral hypoglycemic agents(OHA)and simple insulin intensification therapy on insulin resistance and β cell function of patients with short disease duration and naive type 2 diabetic.Methods Sixty newly diagnosed and naive type 2 diabetic patients(the diabetic duration≤1 year)were randomly divided into two groups,treated with OHA and insulin respectively.Each group included 30 cases and was put on intensive blood glucose control.The targets for blood glucose control were fasting blood glucose less than 6.0mmol/L,and two hours postprandial blood glucose less than 8.0mmoL/L,which were achieved in 5-10 days,and had been lasted for 4 weeks.Before and after intensive therapy,intravenous glucose tolerance test(IVGTT)which was performed to calculate AUCIns0-10min,Homa A and Homa B between two groups were compared.Results After intensive treatment,AUCIns0-10min and Homa B of the two groups increased,but Homa A decreased.There were no significant differences between two groups.Conclusion The same excellent improvement of insulin sensitivity and β cell function could be obtained by two ways of intensive glucose treatment in short disease duration and naive type 2 diabetic patients.