CAJ | 학술논문

温度敏感型高分子凝胶因能随环境温度的变化发生可逆的相变或体积变化而被作为药物控释体系的载体之一,成为近年来研究的热点.但目前许多温敏型凝胶的非生物降解性限制了其在生物医学领域中的实际应用.因此,在温敏聚合物中引入生物降解性物质,使凝胶同时具有温敏和生物降解功能,将其用于药物释放体系,具有广阔的应用前景.结合近年来的研究报道,阐述了几类重要的温敏可生物降解凝胶及其在药物控制释放中的应用.
온도민감형고분자응효인능수배경온도적변화발생가역적상변혹체적변화이피작위약물공석체계적재체지일,성위근년래연구적열점.단목전허다온민형응효적비생물강해성한제료기재생물의학영역중적실제응용.인차,재온민취합물중인입생물강해성물질,사응효동시구유온민화생물강해공능,장기용우약물석방체계,구유엄활적응용전경.결합근년래적연구보도,천술료궤류중요적온민가생물강해응효급기재약물공제석방중적응용.
Thermosensitive gel which exhibits a reversible phase transition in response to temperature is studied as a hotly discussed topic these years, for it can be used as a supporter of drug controlled release system. However,most of these gels are non-biodegradable and then their applications in biomedical areas are limited. Biodegradable linkages introduced into the polymer backbone will lead to the gel with both sensitive thermoresponse and biodegradability, the novel gels have attractive potential applications in the development of drug delivery systems. On the basis of pertinent documents,the scope of this paper is to review some important temperature sensitive biodegradable gels and their applications in drug controlled release.