中国抗生素杂志
中國抗生素雜誌
중국항생소잡지
CHINESE JOURNAL OF ANTIBIOTICS
2010年
4期
274-276,285
,共4页
6-APA%阿莫西林%合成
6-APA%阿莫西林%閤成
6-APA%아막서림%합성
6-APA%Amoxicillin%Synthesis
目的 阿莫西林合成工艺的改进.方法 以6-APA为起始原料,工艺路线为6-APA胺盐溶液与混合酸酐反应得阿莫西林.结果 目标产物的结构经元素分析、IR、~1H-NMR、~(13)C-NMR谱数据确证,且质量符合国家2005版药典.结论 改进后的工艺新解决了原工艺酸酐反应不完全及水解等问题,操作简单、产品质量稳定、收率高、成本低、更适合工业化生产.
目的 阿莫西林閤成工藝的改進.方法 以6-APA為起始原料,工藝路線為6-APA胺鹽溶液與混閤痠酐反應得阿莫西林.結果 目標產物的結構經元素分析、IR、~1H-NMR、~(13)C-NMR譜數據確證,且質量符閤國傢2005版藥典.結論 改進後的工藝新解決瞭原工藝痠酐反應不完全及水解等問題,操作簡單、產品質量穩定、收率高、成本低、更適閤工業化生產.
목적 아막서림합성공예적개진.방법 이6-APA위기시원료,공예로선위6-APA알염용액여혼합산항반응득아막서림.결과 목표산물적결구경원소분석、IR、~1H-NMR、~(13)C-NMR보수거학증,차질량부합국가2005판약전.결론 개진후적공예신해결료원공예산항반응불완전급수해등문제,조작간단、산품질량은정、수솔고、성본저、경괄합공업화생산.
Objective To improve the synthetic technology of amoxicillin.Methods Amoxicillin was synthesized from a main raw material 6-aminopenicillanic acid(6-APA)and acid anhydrides by nucleophilic substitution.Results The structure of final product was confirmed by elemental analysis,IR,~1H-NMR,~(13)C-NMR and the qualities of final product measure up CP2005.Conclusion Compared with original process,the problems of the reaction of mixed acid anhydrides and hydrolyzation were solved.The improved process has high yield,low cost and is easy to operate,while the quality of products is much more stable and suitable for industrial production.
