中国实验诊断学
中國實驗診斷學
중국실험진단학
CHINESE JOURNAL OF LABORATORY DIAGNOSIS
2009年
7期
886-888
,共3页
脑血栓形成%动脉粥样硬化%基因多态性%eNOS
腦血栓形成%動脈粥樣硬化%基因多態性%eNOS
뇌혈전형성%동맥죽양경화%기인다태성%eNOS
cerebral thrombosis%Atherosclerosis%Polymorphism%eNOS
目的 研究内皮型一氧化氮合酶基因多态性性与吉林汉族人群脑血栓形成的关系.方法 收集120例患有脑血栓形成的吉林汉族患者和102例年龄、性别相匹配的健康对照者,用聚合酶链反应限制性片段长度多态性(PCR-RFLP)技术检测其基因型,用以研究一氧化氮合酶G894T基因变异在两组中的差异.结果 eNOS的基因多态性在脑血栓形成组和对照组中的差异有显著性,经调整后的OR值为2.16(95%CI:1.12-4.16,P<0.05).T等位基因频率在两组中也存在着显著性差异,经调整后的OR值为2.08,(95%CI:1.17-3.71,P<0.05).结论 eNOS基因G894T多态性与吉林汉族人群脑血栓形成的发病具有相关性,T等位基因可能是脑血栓形成发病的遗传易感基因.
目的 研究內皮型一氧化氮閤酶基因多態性性與吉林漢族人群腦血栓形成的關繫.方法 收集120例患有腦血栓形成的吉林漢族患者和102例年齡、性彆相匹配的健康對照者,用聚閤酶鏈反應限製性片段長度多態性(PCR-RFLP)技術檢測其基因型,用以研究一氧化氮閤酶G894T基因變異在兩組中的差異.結果 eNOS的基因多態性在腦血栓形成組和對照組中的差異有顯著性,經調整後的OR值為2.16(95%CI:1.12-4.16,P<0.05).T等位基因頻率在兩組中也存在著顯著性差異,經調整後的OR值為2.08,(95%CI:1.17-3.71,P<0.05).結論 eNOS基因G894T多態性與吉林漢族人群腦血栓形成的髮病具有相關性,T等位基因可能是腦血栓形成髮病的遺傳易感基因.
목적 연구내피형일양화담합매기인다태성성여길림한족인군뇌혈전형성적관계.방법 수집120례환유뇌혈전형성적길림한족환자화102례년령、성별상필배적건강대조자,용취합매련반응한제성편단장도다태성(PCR-RFLP)기술검측기기인형,용이연구일양화담합매G894T기인변이재량조중적차이.결과 eNOS적기인다태성재뇌혈전형성조화대조조중적차이유현저성,경조정후적OR치위2.16(95%CI:1.12-4.16,P<0.05).T등위기인빈솔재량조중야존재착현저성차이,경조정후적OR치위2.08,(95%CI:1.17-3.71,P<0.05).결론 eNOS기인G894T다태성여길림한족인군뇌혈전형성적발병구유상관성,T등위기인가능시뇌혈전형성발병적유전역감기인.
Objective To study the relationship between polymorphisms of endothelial constitutive nitric oxide synthase gene and Cerbral Thrombosis in Han people of Jilin province.Methods We investigated the G894T mutations in the eNOS gene in 120 patients with cerebral thrombosis of Jilin province and 102 age-and sex-matched healthy controls.Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP)were used for genotyping.Results There was significant difference in polymorphisms between patients with cerebral thrombosis and controls,the adjusted odds ratio was 2.16(95%CI:1.12-4.16,P<0.05).There was significant difference in frequencies of allele T between Cerbral thrombosis and control groups.The adjusted odds ratio was 2.08(95%CI:1.17-3.71,P<0.05).Conclusion eNOS G894T polymorphism was associated with cerbral thrombosis in Han people of Jilin province,and T allele may be a genetic risk factor of cerbral thrombosis.
