CAJ | 학술논문

目的:了解严重药品不良反应(ADR)发生的特点和规律,促进ADR监测,为临床安全用药提供参考.方法:收集我院2006年11月～2008年12月报告的29例严重ADR病例,按ADR发生的关联性因素进行统计、分析与评价.结果:本组资料中,引起严重ADR的前两位药品是抗感染药和中药注射剂,其中喹诺酮类药物引起中枢神经系统损害、中药注射剂引起过敏性休克和呼吸系统损害较多见;静脉给药是引起严重ADR最多的给药途径;多见于并用3种或以上药品的病例.结论:重视ADR监测工作,特别是抗感染药和中药注射剂的安全性监测;加强临床合理用药,以减少严重ADR的发生.
목적:료해엄중약품불량반응(ADR)발생적특점화규률,촉진ADR감측,위림상안전용약제공삼고.방법:수집아원2006년11월～2008년12월보고적29례엄중ADR병례,안ADR발생적관련성인소진행통계、분석여평개.결과:본조자료중,인기엄중ADR적전량위약품시항감염약화중약주사제,기중규낙동류약물인기중추신경계통손해、중약주사제인기과민성휴극화호흡계통손해교다견;정맥급약시인기엄중ADR최다적급약도경;다견우병용3충혹이상약품적병례.결론:중시ADR감측공작,특별시항감염약화중약주사제적안전성감측;가강림상합리용약,이감소엄중ADR적발생.
Objective: To investigate the characteristics and disciplinarian of serious adverse drug reactions (ADR) and to promote ADR monitoring so that to guide clinical practice. Methods: From November 2006 to December 2008, we crected 29 severe ADR cases in our hospital, analyzed statistically and evaluated based on the ADR causality judgment criteria. Results: The antibiotics and traditional Chinese medicine injection caused the higher proportion of serious ADR. The quinolones harmed to central nervous system and the traditional Chinese medicine injection caused irritability shock or harmed to breath system. Injection is the main way for administration, and most of them were combined more than three drugs. Conclusion: Great importance should be attached to the safety monitoring of antibiotics and traditional Chinese medicine injection, and improve rational drug use to guard against severe ADR.