中国临床康复
中國臨床康複
중국림상강복
CHINESE JOURNAL OF CLINICAL REHABILITATION
2005年
45期
174-175
,共2页
于素清%初开秋%李雨升%韩建香%王麟
于素清%初開鞦%李雨升%韓建香%王麟
우소청%초개추%리우승%한건향%왕린
脑血管意外%内皮缩血管肽类%昼夜节律
腦血管意外%內皮縮血管肽類%晝夜節律
뇌혈관의외%내피축혈관태류%주야절률
背景:脑卒中的发病有早晨高、晚上低的早晚规律变化,而脑血栓患者血浆内皮素浓度的变化及与脑血栓发病之间的关系尚不十分清楚.目的:探讨血浆内皮素水平对脑血栓急性期患者24 h内动态变化规律及其与发病的相关性.设计:病例-对照实验.单位:青岛大学医学院附属医院放免中心和检验科联合进行课题研究.对象:选择2002-01/2003-01在青岛大学医学院附属医院神经内科住院脑血栓患者32例,男20例,女12例;平均年龄(61.5±4.1)岁.既往合并糖尿病和高血压史者10例,单纯有高血压史者8例,糖尿病史者1例,无高血压、糖尿病史者13例.同期选择在本院健康查体者30例为对照组,男13例,女17例;平均年龄(58.1±6.25)岁.所有参加者对本实验知情同意. 方法:采用放射免疫分析对32例脑血栓患者和20例健康人在2:00,8:00,14:00,20:00时,测定其血浆内皮素水平的动态变化.主要观察指标:①脑血栓组与对照组24 h内4个时间点血浆内皮素水平.②有无病史的脑血栓患者24 h内4个时间点血浆内皮素水平.结果:参加实验的32例脑血栓患者和30例对照组血样检测结果全部进入统计分析.①脑血栓患者昼夜血浆内皮素水平明显高于对照组(t=29.1～30.5,P＜0.001),在24 h内2:00内皮素水平最低(69.96±3.92)ng/L,8:00最高(78.55±3.80)ng/L,(t=5.67,P＜0.01).②有高血压和糖尿病病史的脑血栓患者24 h内(2:00,8:00,14:00,20:00)的内皮素水平均显著高于无高血压,糖尿病病史者[(73.28±7.89),(64.52±5.29)ng/L;(82.39±8.62),(75.81±5.14)ng/L;(81.39±8.62),(70.32±5.97)ng/L;(82.47±5.04),(65.27±5.14)ng/L,(t=2.11～5.17,P＜0.05～0.01)].结论:脑血栓急性期患者血浆内皮素水平24 h内有早晨高和晚上低的节律性变化,其变化与脑血栓发病早晨为高发时间的现象一致.
揹景:腦卒中的髮病有早晨高、晚上低的早晚規律變化,而腦血栓患者血漿內皮素濃度的變化及與腦血栓髮病之間的關繫尚不十分清楚.目的:探討血漿內皮素水平對腦血栓急性期患者24 h內動態變化規律及其與髮病的相關性.設計:病例-對照實驗.單位:青島大學醫學院附屬醫院放免中心和檢驗科聯閤進行課題研究.對象:選擇2002-01/2003-01在青島大學醫學院附屬醫院神經內科住院腦血栓患者32例,男20例,女12例;平均年齡(61.5±4.1)歲.既往閤併糖尿病和高血壓史者10例,單純有高血壓史者8例,糖尿病史者1例,無高血壓、糖尿病史者13例.同期選擇在本院健康查體者30例為對照組,男13例,女17例;平均年齡(58.1±6.25)歲.所有參加者對本實驗知情同意. 方法:採用放射免疫分析對32例腦血栓患者和20例健康人在2:00,8:00,14:00,20:00時,測定其血漿內皮素水平的動態變化.主要觀察指標:①腦血栓組與對照組24 h內4箇時間點血漿內皮素水平.②有無病史的腦血栓患者24 h內4箇時間點血漿內皮素水平.結果:參加實驗的32例腦血栓患者和30例對照組血樣檢測結果全部進入統計分析.①腦血栓患者晝夜血漿內皮素水平明顯高于對照組(t=29.1～30.5,P＜0.001),在24 h內2:00內皮素水平最低(69.96±3.92)ng/L,8:00最高(78.55±3.80)ng/L,(t=5.67,P＜0.01).②有高血壓和糖尿病病史的腦血栓患者24 h內(2:00,8:00,14:00,20:00)的內皮素水平均顯著高于無高血壓,糖尿病病史者[(73.28±7.89),(64.52±5.29)ng/L;(82.39±8.62),(75.81±5.14)ng/L;(81.39±8.62),(70.32±5.97)ng/L;(82.47±5.04),(65.27±5.14)ng/L,(t=2.11～5.17,P＜0.05～0.01)].結論:腦血栓急性期患者血漿內皮素水平24 h內有早晨高和晚上低的節律性變化,其變化與腦血栓髮病早晨為高髮時間的現象一緻.
배경:뇌졸중적발병유조신고、만상저적조만규률변화,이뇌혈전환자혈장내피소농도적변화급여뇌혈전발병지간적관계상불십분청초.목적:탐토혈장내피소수평대뇌혈전급성기환자24 h내동태변화규률급기여발병적상관성.설계:병례-대조실험.단위:청도대학의학원부속의원방면중심화검험과연합진행과제연구.대상:선택2002-01/2003-01재청도대학의학원부속의원신경내과주원뇌혈전환자32례,남20례,녀12례;평균년령(61.5±4.1)세.기왕합병당뇨병화고혈압사자10례,단순유고혈압사자8례,당뇨병사자1례,무고혈압、당뇨병사자13례.동기선택재본원건강사체자30례위대조조,남13례,녀17례;평균년령(58.1±6.25)세.소유삼가자대본실험지정동의. 방법:채용방사면역분석대32례뇌혈전환자화20례건강인재2:00,8:00,14:00,20:00시,측정기혈장내피소수평적동태변화.주요관찰지표:①뇌혈전조여대조조24 h내4개시간점혈장내피소수평.②유무병사적뇌혈전환자24 h내4개시간점혈장내피소수평.결과:삼가실험적32례뇌혈전환자화30례대조조혈양검측결과전부진입통계분석.①뇌혈전환자주야혈장내피소수평명현고우대조조(t=29.1～30.5,P＜0.001),재24 h내2:00내피소수평최저(69.96±3.92)ng/L,8:00최고(78.55±3.80)ng/L,(t=5.67,P＜0.01).②유고혈압화당뇨병병사적뇌혈전환자24 h내(2:00,8:00,14:00,20:00)적내피소수평균현저고우무고혈압,당뇨병병사자[(73.28±7.89),(64.52±5.29)ng/L;(82.39±8.62),(75.81±5.14)ng/L;(81.39±8.62),(70.32±5.97)ng/L;(82.47±5.04),(65.27±5.14)ng/L,(t=2.11～5.17,P＜0.05～0.01)].결론:뇌혈전급성기환자혈장내피소수평24 h내유조신고화만상저적절률성변화,기변화여뇌혈전발병조신위고발시간적현상일치.
BACKGROUND: High incidence rate in the morning and low incidence rate in the evening is the regularity of stroke; however, there are no clear reports on changes of concentration of plasma endothelins and its relationship with onset of cerebral thrombus.OBJECTIVE: To investigate dynamic regularity of plasma endothelins in patients with acute cerebral thrombus within 24 hours and its correlation with episode.DESIGN: Case-controlled study.SETTING: Center of Radio-immunology and Department of Laboratory of Affiliated Hospital of Medical College of Qingdao University.PARTICIPANTS: Totally 32 patients with cerebral thrombus were selected from Neurological Department of Affiliated Hospital of Medical College of Qingdao University from January 2002 to January 2003. There were 20males and 12 females with mean age of (61.5±4.1) years. Ten patients had history of diabetes mellitus combined with hypertension, 8 had history of hypertension, 1 had history of diabetes mellitus, and 13 did not have history of diabetes mellitus and hypertension. Another 30 healthy subjects were selected from the same hospital including 13 males and 17 females with the mean age of (58.1±6.25) years. Informed consent was obtained from all subjects.METHODS: Radio-immune analysis was used to determine the dynamic changes of plasma-endothelins level in 32 patients with cerebral thrombus and 20 healthy subjects at 2, 8, 14 and 20 o'clock.MAIN OUTCOME MEASURES: ① Plasma-endothelins level of patients in cerebral thrombus group and control group at the four time points within 24 hours; ② Plasma-endothelins level of patients with or without cerebral thrombus at the four time points within 24 hours.RESULTS: Totally 32 patients with cerebral thrombus and 30 subjects in control group entered the final analysis. ① Plasma-endothelins level in cerebral thrombus group day and night was higher than that in the control group (t=29.1-30.5, P ＜ 0.001). The level was the lowest [(69.96±3.92) ng/L] at 2 o'clock within 24 hours but the highest at 8 o'clock [(78.55±3.80) ng/L,(t=5.67, P ＜ 0.01)]. ② Levels of endothelins in patients with history of hypertension and cerebral thrombus were obviously higher than those in patients without history of hypertension and cerebral thrombus at 2, 8, 14 and 20 o 'clock within 24 hours [(73.28±7.89), (64.52±5.29) ng/L; (82.39±8.62),(75.81±5.14) ng/L; (81.39±8.62), (70.32±5.97) ng/L; (82.47±5.04),(65.27±5.14) ng/L, (t=2.11-5.17, P ＜ 0.05-0.01)].CONCLUSION: Plasma-endothelins level in patients with acute cerebral thrombus has rhythm changes within 24 hours. The changes are high in the morning and low in the evening, and this is accorded with high onset of cerebral thrombus in the morning.
