CAJ | 학술논문

目的：评价单硝酸异山梨酯(商品名：长效异乐定)治疗慢性稳定型心绞痛的疗效。方法：对161例慢性稳定型心绞痛患者进行长效异乐定与硝酸异山梨酯(消心痛)对比治疗的临床观察，并采用Holter 24h心肌缺血总负荷（TIB）及放射核素心肌灌注显像评估缺血心肌面积（IMA）。结果：长效异乐定治疗3个月TIB显著低于治疗前，6个月则更显著（P<0.01），12个月仍保持稳定的疗效，与对照组比较有显著性差异。同时显示长效异乐定治疗6及12个月IMA显著减少，较对照组有显著差异。临床随访1年治疗组总缺血相关事件明显低于对照组。2组因不良反应而停药者均<2%。结论：长效异乐定长期治疗慢性稳定型心绞痛具有长期抗心肌缺血和减少缺血相关事件的作用。
목적：평개단초산이산리지(상품명：장효이악정)치료만성은정형심교통적료효。방법：대161례만성은정형심교통환자진행장효이악정여초산이산리지(소심통)대비치료적림상관찰，병채용Holter 24h심기결혈총부하（TIB）급방사핵소심기관주현상평고결혈심기면적（IMA）。결과：장효이악정치료3개월TIB현저저우치료전，6개월칙경현저（P<0.01），12개월잉보지은정적료효，여대조조비교유현저성차이。동시현시장효이악정치료6급12개월IMA현저감소，교대조조유현저차이。림상수방1년치료조총결혈상관사건명현저우대조조。2조인불량반응이정약자균<2%。결론：장효이악정장기치료만성은정형심교통구유장기항심기결혈화감소결혈상관사건적작용。
Objective:To assess the effects of long acting isosorbide mononitrate (Elantan Long) for chronic stable angina pectoris.Methods:161 patients with chronic stable angina pectoris were treated with Elantan Long or isosorbide dinitrate(ISDN).In comparison with ISDN,the anti-ischemic effect of Elantan Long was assessed by total ischemic burden (TIB) with Holter monitoring and ischemic myocardial area(IMA) with JT99m,D,Zc-MIBI myocardial imaging.Results:The TIB and IMA of patients treated with Elantan Long for 3,6,and 12 months were lower than those with ISDN.The ischemic related cardial events were also fewer than those with ISDN.Conclusion:Elantan Long has long-term anti-ischemic effects and reduces the incidence of ischemic-related events of patients with chronic stable angina pectoris.