CAJ | 학술논문

应用RT-PCR技术对51例肺癌手术标本及对应的癌旁组织中GST-π基因的表达情况进行定量研究。结果表明，在癌变组织中GST-π的表达明显高于癌旁组织，且与临床病理类型、分期及分化程度无关，对临床化疗方案的制订具有一定的指导意义。该组患者术前未经抗癌治疗，提示肺癌先天性耐药中GST-π起重要作用。
응용RT-PCR기술대51례폐암수술표본급대응적암방조직중GST-π기인적표체정황진행정량연구。결과표명，재암변조직중GST-π적표체명현고우암방조직，차여림상병리류형、분기급분화정도무관，대림상화료방안적제정구유일정적지도의의。해조환자술전미경항암치료，제시폐암선천성내약중GST-π기중요작용。
Expression of the GST-π in 51 cases of lung cancer was researched by quantitative RT-PCR. The results suggested that the expression of GST-π was significantly higher in lung cancer than in normal tissues adjacent to cancer, and tumoral native resistance might be dominant in tumoral resistance to chemotherapeutic drugs. No relationship was found between GST-π expression and clinicopathological parameters including tumor class, stage and differentiation. The study of GST-π expression is of importance in the evaluation of tumoral resistance to anticancer drugs.