CAJ | 학술논문

目的比较氯硝西泮和地西泮针剂治疗癫痫状态的疗效和安全性。方法符合癫痫状态诊断标准的56例住院患者，随机分为两组进行对照研究。分别给与氯硝西泮1～14mg/d和地西泮5～100mg/d，以发作频率减少50～75％和75％以上作为治疗有效和显效的评定标准，以TESS和实验室检查评价药物副反应。结果氯硝西泮治疗有效率为92.9％，地西泮为71.4％，两者有显著性差异；显效率氯硝西泮为78.6％，地西泮为60.7％，两者无显著差异。即刻止痫作用两者相仿。平均药效持续时间氯硝西泮显著长于地西泮。药物副反应两者相似。结论氯硝西泮治疗癫痫状态有效、安全，起效迅速，药效持续时间长。
목적비교록초서반화지서반침제치료전간상태적료효화안전성。방법부합전간상태진단표준적56례주원환자，수궤분위량조진행대조연구。분별급여록초서반1～14mg/d화지서반5～100mg/d，이발작빈솔감소50～75％화75％이상작위치료유효화현효적평정표준，이TESS화실험실검사평개약물부반응。결과록초서반치료유효솔위92.9％，지서반위71.4％，량자유현저성차이；현효솔록초서반위78.6％，지서반위60.7％，량자무현저차이。즉각지간작용량자상방。평균약효지속시간록초서반현저장우지서반。약물부반응량자상사。결론록초서반치료전간상태유효、안전，기효신속，약효지속시간장。
Objective To compare efficacy and safety of clonazepam with diazepam in treating epilepsy.Methods 56 epilepsy patients were randomly assigned to clonazepam or diazepam treatment.The frequency of epilepsy decreased 50-75％ and 75％ above had regarded as "effective" and "effective significantly" standard respectively.Results "effective" rates of clonazepam and diazepam had significant difference (92.9％ vs.71.4％ ),while the difference of their "effective significantly" rate was not significant (78.6％ vs.60.7％ ).Side effects of these two drugs were similar.Conclusion Clonazepam was effective and safe in treating epilepsy.