CAJ | 학술논문

通过颗粒粒径和粒谱对悬浮剂贮存物理稳定性影响研究，明确了悬浮剂剂型加工中研磨时间与制剂悬浮颗粒粒径和粒谱分布的关系。结果表明，在选定了适当助剂、确定了加工工艺的条件下，通过调整研磨时间、降低悬浮颗粒粒径和粒谱分布，可以改善悬浮体系的物理稳定性。另外，由于研磨时间的延长、粒径变小所带来的悬浮体系粘度的增加，对制剂物理稳定性也是非常有利的。
통과과립립경화립보대현부제저존물리은정성영향연구，명학료현부제제형가공중연마시간여제제현부과립립경화립보분포적관계。결과표명，재선정료괄당조제、학정료가공공예적조건하，통과조정연마시간、강저현부과립립경화립보분포，가이개선현부체계적물리은정성。령외，유우연마시간적연장、립경변소소대래적현부체계점도적증가，대제제물리은정성야시비상유리적。
The relationship between milling time of SC formulation processing with particle size and size distribution in suspension was described by studying the relationship of SC stability with particle size and size distribution. The result showed suspension physical stability could be improved by adjustment of milling time and decrease of particle size and size distribution, while suitable adjuvant and processing conditions were selected. Increase the viscosity of the suspension due to longer milling time and smaller particle size, would be more helpful to physical stability of the suspension.