CAJ | 학술논문

目的研究油茶皂苷(SQS)预适应保护作用及NO的关系。方法以ISO诱发大鼠心肌缺血损伤为模型，使用特异性NO合成抑制剂Methyleneblue(MET)测定大鼠ECG及CPK活性，FFA和腺苷含量。结果预适应ivSQS能有效地保护ISO所致大鼠心肌损伤；先ivMET后再给予SQS，则SQS对心肌损伤的保护作用明显减弱。结论 SQS对ISO所致心肌缺血大鼠可产生药理性预适应保护作用，该作用由NO所介导。
목적 연구유다조감(SQS)예괄응보호작용급NO적관계。방법 이ISO유발대서심기결혈손상위모형，사용특이성NO합성억제제Methyleneblue(MET)측정대서ECG급CPK활성，FFA화선감함량。결과 예괄응ivSQS능유효지보호ISO소치대서심기손상；선ivMET후재급여SQS，칙SQS대심기손상적보호작용명현감약。결론 SQS대ISO소치심기결혈대서가산생약이성예괄응보호작용，해작용유NO소개도。
Object To study the protective effect and pharmacologicalischemic preconditioning of sasanquasaponin (SQS) on intact rat heart and its relationship with NO. Methods A model of rat myocardial ischemia induced by sc injection of isoproterenol (ISO) was prepared, and after the administration of selective NO synthesis inhibitor methylene blue (MET), the ECG, serum creatine kinase (CK) activity, free fatty acid (FFA) and adenosine contents were determined. Results Preconditioning iv injection of SQS can effectively protect the myocardium from ischemia induced by ISO. The cardio protective effect was significantly attenuated when the NO synthesis inhibitor MET were injected prior to SQS. Conclusion SQS can effectively protect myocardium ischemia induced by ISO and the protection is most likely to be mediated by NO.